node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BET3L | TRAPPC1 | ENSP00000357591 | ENSP00000302783 | BET3 like (S. cerevisiae); May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity) | trafficking protein particle complex 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi | 0.946 |
BET3L | TRAPPC2 | ENSP00000357591 | ENSP00000392495 | BET3 like (S. cerevisiae); May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity) | trafficking protein particle complex 2; Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi | 0.950 |
BET3L | TRAPPC4 | ENSP00000357591 | ENSP00000436005 | BET3 like (S. cerevisiae); May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity) | trafficking protein particle complex 4; May play a role in vesicular transport from endoplasmic reticulum to Golgi | 0.914 |
BET3L | TRAPPC8 | ENSP00000357591 | ENSP00000283351 | BET3 like (S. cerevisiae); May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity) | trafficking protein particle complex 8; May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage | 0.934 |
FANCD2 | TP53 | ENSP00000287647 | ENSP00000269305 | Fanconi anemia, complementation group D2; Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induc [...] | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.508 |
RACGAP1 | TP53 | ENSP00000309871 | ENSP00000269305 | Rac GTPase activating protein 1; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase acti [...] | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.453 |
TECPR1 | TRAPPC11 | ENSP00000404923 | ENSP00000335371 | tectonin beta-propeller repeat containing 1; Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes- acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation | trafficking protein particle complex 11 | 0.721 |
TECPR1 | TRAPPC12 | ENSP00000404923 | ENSP00000324318 | tectonin beta-propeller repeat containing 1; Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes- acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation | trafficking protein particle complex 12; May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage | 0.771 |
TECPR1 | TRAPPC8 | ENSP00000404923 | ENSP00000283351 | tectonin beta-propeller repeat containing 1; Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes- acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation | trafficking protein particle complex 8; May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage | 0.749 |
TP53 | FANCD2 | ENSP00000269305 | ENSP00000287647 | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | Fanconi anemia, complementation group D2; Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induc [...] | 0.508 |
TP53 | RACGAP1 | ENSP00000269305 | ENSP00000309871 | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | Rac GTPase activating protein 1; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase acti [...] | 0.453 |
TP53 | TRAPPC11 | ENSP00000269305 | ENSP00000335371 | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | trafficking protein particle complex 11 | 0.422 |
TRAPPC1 | BET3L | ENSP00000302783 | ENSP00000357591 | trafficking protein particle complex 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi | BET3 like (S. cerevisiae); May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity) | 0.946 |
TRAPPC1 | TRAPPC11 | ENSP00000302783 | ENSP00000335371 | trafficking protein particle complex 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi | trafficking protein particle complex 11 | 0.473 |
TRAPPC1 | TRAPPC12 | ENSP00000302783 | ENSP00000324318 | trafficking protein particle complex 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi | trafficking protein particle complex 12; May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage | 0.498 |
TRAPPC1 | TRAPPC2 | ENSP00000302783 | ENSP00000392495 | trafficking protein particle complex 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi | trafficking protein particle complex 2; Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi | 0.963 |
TRAPPC1 | TRAPPC3 | ENSP00000302783 | ENSP00000362261 | trafficking protein particle complex 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi | trafficking protein particle complex 3; May play a role in vesicular transport from endoplasmic reticulum to Golgi | 0.998 |
TRAPPC1 | TRAPPC4 | ENSP00000302783 | ENSP00000436005 | trafficking protein particle complex 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi | trafficking protein particle complex 4; May play a role in vesicular transport from endoplasmic reticulum to Golgi | 0.919 |
TRAPPC1 | TRAPPC8 | ENSP00000302783 | ENSP00000283351 | trafficking protein particle complex 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi | trafficking protein particle complex 8; May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage | 0.988 |
TRAPPC11 | TECPR1 | ENSP00000335371 | ENSP00000404923 | trafficking protein particle complex 11 | tectonin beta-propeller repeat containing 1; Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes- acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation | 0.721 |