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ZMYM6 ZMYM6 ZMYM3 ZMYM3 UBQLNL UBQLNL ZNF280B ZNF280B RPUSD1 RPUSD1 QRICH1 QRICH1 ZNF280A ZNF280A ZMYM4 ZMYM4 CDR2L CDR2L ZMYM2 ZMYM2 NXF2B NXF2B RPUSD2 RPUSD2 NXF2 NXF2 CDR2 CDR2 NXF3 NXF3 FGFR1OP2 FGFR1OP2 NXF1 NXF1 CENPE CENPE UBQLN4 UBQLN4 NXF5 NXF5 TLK1 TLK1 SLMAP SLMAP UBQLN1 UBQLN1 TLK2 TLK2 CDT1 CDT1 UBQLN2 UBQLN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
RPUSD1RNA pseudouridylate synthase domain containing 1 (312 aa)
FGFR1OP2FGFR1 oncogene partner 2; May be involved in wound healing pathway (By similarity) (253 aa)
CENPEcentromere protein E, 312kDa; Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during mitosis. Is a slow plus end- directed motor whose activity is essential for metaphase chromosome alignment. Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule- dependent motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking kinetochores to dynami [...] (2701 aa)
CDR2cerebellar degeneration-related protein 2, 62kDa (454 aa)
TLK2tousled-like kinase 2; Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy (750 aa)
NXF1nuclear RNA export factor 1; Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (619 aa)
SLMAPsarcolemma associated protein (811 aa)
CDT1chromatin licensing and DNA replication factor 1; Cooperates with CDC6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene (546 aa)
ZNF280Azinc finger protein 280A; May function as a transcription factor (542 aa)
ZMYM3zinc finger, MYM-type 3; Plays a role in the regulation of cell morphology and cytoskeletal organization (1370 aa)
ZMYM4zinc finger, MYM-type 4; Plays a role in the regulation of cell morphology and cytoskeletal organization (1548 aa)
RPUSD2RNA pseudouridylate synthase domain containing 2 (545 aa)
NXF2nuclear RNA export factor 2 (626 aa)
CDR2Lcerebellar degeneration-related protein 2-like (465 aa)
UBQLN2ubiquilin 2; Increases the half-life of proteins destined to be degraded by the proteasome; may modulate proteasome-mediated protein degradation (624 aa)
ZMYM6zinc finger, MYM-type 6 (1325 aa)
QRICH1glutamine-rich 1 (776 aa)
ZNF280Bzinc finger protein 280B; May function as a transcription factor (543 aa)
UBQLN4ubiquilin 4; Plays a role in the regulation of proteasomal protein degradation. Depending on the case, may promote or inhibit proteasomal protein degradation (601 aa)
NXF2Bnuclear RNA export factor 2B; Involved in the export of mRNA from the nucleus to the cytoplasm (626 aa)
UBQLN1ubiquilin 1; Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors (By similarity). Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2 degradation (589 aa)
UBQLNLubiquilin-like (475 aa)
ZMYM2zinc finger, MYM-type 2 (1377 aa)
NXF3nuclear RNA export factor 3; May function as a tissue-specific nuclear mRNA export factor (531 aa)
TLK1tousled-like kinase 1; Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at ’Ser-10’ (766 aa)
NXF5nuclear RNA export factor 5 (365 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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