Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | RPUSD1 | RNA pseudouridylate synthase domain containing 1 (312 aa) | ||
 | FGFR1OP2 | FGFR1 oncogene partner 2; May be involved in wound healing pathway (By similarity) (253 aa) | ||
 | CENPE | centromere protein E, 312kDa; Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during mitosis. Is a slow plus end- directed motor whose activity is essential for metaphase chromosome alignment. Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule- dependent motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking kinetochores to dynami [...] (2701 aa) | ||
 | ZNF280D | zinc finger protein 280D; May function as a transcription factor (979 aa) | ||
 | POGZ | pogo transposable element with ZNF domain (1410 aa) | ||
 | TLK2 | tousled-like kinase 2; Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy (750 aa) | ||
 | SLMAP | sarcolemma associated protein (811 aa) | ||
 | RPUSD4 | RNA pseudouridylate synthase domain containing 4 (377 aa) | ||
 | CDT1 | chromatin licensing and DNA replication factor 1; Cooperates with CDC6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene (546 aa) | ||
 | ZNF280A | zinc finger protein 280A; May function as a transcription factor (542 aa) | ||
 | ZMYM3 | zinc finger, MYM-type 3; Plays a role in the regulation of cell morphology and cytoskeletal organization (1370 aa) | ||
 | ZMYM4 | zinc finger, MYM-type 4; Plays a role in the regulation of cell morphology and cytoskeletal organization (1548 aa) | ||
 | RPUSD2 | RNA pseudouridylate synthase domain containing 2 (545 aa) | ||
 | CDR2L | cerebellar degeneration-related protein 2-like (465 aa) | ||
 | UBQLN2 | ubiquilin 2; Increases the half-life of proteins destined to be degraded by the proteasome; may modulate proteasome-mediated protein degradation (624 aa) | ||
 | ZMYM6 | zinc finger, MYM-type 6 (1325 aa) | ||
 | QRICH1 | glutamine-rich 1 (776 aa) | ||
 | ZNF280B | zinc finger protein 280B; May function as a transcription factor (543 aa) | ||
 | UBQLN4 | ubiquilin 4; Plays a role in the regulation of proteasomal protein degradation. Depending on the case, may promote or inhibit proteasomal protein degradation (601 aa) | ||
 | ZNF280C | zinc finger protein 280C; May function as a transcription factor (737 aa) | ||
 | UBQLN1 | ubiquilin 1; Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors (By similarity). Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2 degradation (589 aa) | ||
 | UBQLNL | ubiquilin-like (475 aa) | ||
 | ZMYM2 | zinc finger, MYM-type 2 (1377 aa) | ||
 | RPUSD3 | RNA pseudouridylate synthase domain containing 3 (351 aa) | ||
 | ELAVL1 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro (326 aa) | ||
 | TLK1 | tousled-like kinase 1; Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at ’Ser-10’ (766 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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