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ELAVL1 ELAVL1 TCERG1L TCERG1L SORBS1 SORBS1 ZNF589 ZNF589 ZNF582 ZNF582 TCERG1 TCERG1 SORBS2 SORBS2 PSMA2 PSMA2 SUMO2 SUMO2 HC3 HC3 CHD4 CHD4 MTF1 MTF1 ENSG00000268107 ENSG00000268107 NAB1 NAB1 EGR2 EGR2 EGR1 EGR1 GLIS1 GLIS1 ZBTB9 ZBTB9 ZNF567 ZNF567 KLF11 KLF11 ZNF362 ZNF362 ZNF384 ZNF384 POU2AF1 POU2AF1 ZNF347 ZNF347 GLIS3 GLIS3 ZNF525 ZNF525
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
PSMA2proteasome (prosome, macropain) subunit, alpha type, 2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation (234 aa)
EGR1early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (543 aa)
EGR2early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 (476 aa)
SORBS2sorbin and SH3 domain containing 2 (1100 aa)
TCERG1transcription elongation regulator 1; Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter (1098 aa)
ZNF582zinc finger protein 582; May be involved in transcriptional regulation (517 aa)
KLF11Kruppel-like factor 11; Transcription factor. Activates the epsilon- and gamma- globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis (512 aa)
GLIS1GLIS family zinc finger 1; Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5’-GACCACCCAC-3’ (By similarity) (620 aa)
NAB1NGFI-A binding protein 1 (EGR1 binding protein 1); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2 (By similarity) (487 aa)
ZNF589zinc finger protein 589; May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA binding-dependent transcriptional repressor (364 aa)
CHD4chromodomain helicase DNA binding protein 4; Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones (1912 aa)
ZNF567zinc finger protein 567; May be involved in transcriptional regulation (616 aa)
ZNF384zinc finger protein 384; Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1 (By similarity) (577 aa)
SORBS1sorbin and SH3 domain containing 1 (1292 aa)
TCERG1Ltranscription elongation regulator 1-like (586 aa)
MTF1metal-regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE) (753 aa)
ZNF362zinc finger protein 362; May be involved in transcriptional regulation (420 aa)
GLIS3GLIS family zinc finger 3; Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5’-GACCACCCAC-3’ (By similarity) (930 aa)
POU2AF1POU class 2 associating factor 1; Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers (256 aa)
ZBTB9zinc finger and BTB domain containing 9 (473 aa)
ELAVL1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro (326 aa)
ZNF347zinc finger protein 347; May be involved in transcriptional regulation (840 aa)
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] (95 aa)
ZNF525zinc finger protein 525; May be involved in transcriptional regulation (479 aa)
HC3Proteasome subunit alpha type-2 ; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation (234 aa)
ENSG00000268107Uncharacterized protein (59 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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