node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHD4 | NAB1 | ENSP00000349508 | ENSP00000336894 | chromodomain helicase DNA binding protein 4; Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones | NGFI-A binding protein 1 (EGR1 binding protein 1); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2 (By similarity) | 0.690 |
CHD4 | SUMO2 | ENSP00000349508 | ENSP00000405965 | chromodomain helicase DNA binding protein 4; Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] | 0.818 |
EGR1 | NAB1 | ENSP00000239938 | ENSP00000336894 | early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation | NGFI-A binding protein 1 (EGR1 binding protein 1); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2 (By similarity) | 0.966 |
EGR1 | SP1 | ENSP00000239938 | ENSP00000329357 | early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation | Sp1 transcription factor; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA d [...] | 0.869 |
EGR1 | WT1 | ENSP00000239938 | ENSP00000331327 | early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation | Wilms tumor 1 | 0.705 |
EGR2 | NAB1 | ENSP00000242480 | ENSP00000336894 | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | NGFI-A binding protein 1 (EGR1 binding protein 1); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2 (By similarity) | 0.701 |
EGR3 | NAB1 | ENSP00000318057 | ENSP00000336894 | early growth response 3; Probable transcription factor involved in muscle spindle development | NGFI-A binding protein 1 (EGR1 binding protein 1); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2 (By similarity) | 0.698 |
ELAVL1 | SUMO2 | ENSP00000385269 | ENSP00000405965 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] | 0.424 |
HC3 | PSMA2 | ENSP00000455744 | ENSP00000223321 | Proteasome subunit alpha type-2 ; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation | proteasome (prosome, macropain) subunit, alpha type, 2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation | 0.999 |
KLF3 | SUMO2 | ENSP00000261438 | ENSP00000405965 | Kruppel-like factor 3 (basic); Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity) | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] | 0.473 |
NAB1 | CHD4 | ENSP00000336894 | ENSP00000349508 | NGFI-A binding protein 1 (EGR1 binding protein 1); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2 (By similarity) | chromodomain helicase DNA binding protein 4; Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones | 0.690 |
NAB1 | EGR1 | ENSP00000336894 | ENSP00000239938 | NGFI-A binding protein 1 (EGR1 binding protein 1); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2 (By similarity) | early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation | 0.966 |
NAB1 | EGR2 | ENSP00000336894 | ENSP00000242480 | NGFI-A binding protein 1 (EGR1 binding protein 1); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2 (By similarity) | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | 0.701 |
NAB1 | EGR3 | ENSP00000336894 | ENSP00000318057 | NGFI-A binding protein 1 (EGR1 binding protein 1); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2 (By similarity) | early growth response 3; Probable transcription factor involved in muscle spindle development | 0.698 |
NAB1 | SUMO2 | ENSP00000336894 | ENSP00000405965 | NGFI-A binding protein 1 (EGR1 binding protein 1); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2 (By similarity) | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] | 0.644 |
NAB1 | ZNF362 | ENSP00000336894 | ENSP00000362527 | NGFI-A binding protein 1 (EGR1 binding protein 1); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2 (By similarity) | zinc finger protein 362; May be involved in transcriptional regulation | 0.482 |
NAB1 | ZNF384 | ENSP00000336894 | ENSP00000354592 | NGFI-A binding protein 1 (EGR1 binding protein 1); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2 (By similarity) | zinc finger protein 384; Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1 (By similarity) | 0.482 |
PSMA2 | HC3 | ENSP00000223321 | ENSP00000455744 | proteasome (prosome, macropain) subunit, alpha type, 2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation | Proteasome subunit alpha type-2 ; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation | 0.999 |
REST | SP1 | ENSP00000311816 | ENSP00000329357 | RE1-silencing transcription factor; Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier | Sp1 transcription factor; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA d [...] | 0.622 |
SP1 | EGR1 | ENSP00000329357 | ENSP00000239938 | Sp1 transcription factor; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA d [...] | early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation | 0.869 |