Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
ENSG00000249319 ENSG00000249319 ADC ADC OTC OTC ARG2 ARG2 ASS1 ASS1 DLG2 DLG2 NOS3 NOS3 NOS2 NOS2 DLG4 DLG4 CAMK2B CAMK2B STUB1 STUB1 GUCY1A2 GUCY1A2 NOS1 NOS1 GUCY1B3 GUCY1B3 UBC UBC PPP3CC PPP3CC GUCY1A3 GUCY1A3 PPP3CA PPP3CA PPP3CB PPP3CB PRKAR2A PRKAR2A PRKAR2B PRKAR2B PRKAR1B PRKAR1B PRKCB PRKCB PRKACG PRKACG PRKAR1A PRKAR1A PRKACB PRKACB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
OTCornithine carbamoyltransferase (354 aa)
STUB1STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates- ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 th [...] (303 aa)
PPP3CCprotein phosphatase 3, catalytic subunit, gamma isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin (512 aa)
ASS1argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity) (412 aa)
ARG2arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders (354 aa)
GUCY1B3guanylate cyclase 1, soluble, beta 3 (619 aa)
PRKAR2Aprotein kinase, cAMP-dependent, regulatory, type II, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase (404 aa)
PRKAR2Bprotein kinase, cAMP-dependent, regulatory, type II, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase (418 aa)
DLG4discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) (767 aa)
ADCarginine decarboxylase (460 aa)
GUCY1A3guanylate cyclase 1, soluble, alpha 3 (690 aa)
NOS3nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity) (1203 aa)
PRKCBprotein kinase C, beta (673 aa)
NOS2nitric oxide synthase 2, inducible (1153 aa)
NOS1nitric oxide synthase 1 (neuronal); Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (1468 aa)
UBCubiquitin C (685 aa)
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells (381 aa)
PRKAR1Bprotein kinase, cAMP-dependent, regulatory, type I, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells (381 aa)
PRKACBprotein kinase, cAMP-dependent, catalytic, beta (398 aa)
DLG2discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) (975 aa)
PRKACGprotein kinase, cAMP-dependent, catalytic, gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus (351 aa)
PPP3CBprotein phosphatase 3, catalytic subunit, beta isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin (525 aa)
PPP3CAprotein phosphatase 3, catalytic subunit, alpha isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1 (521 aa)
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta (666 aa)
ENSG00000249319Uncharacterized protein (293 aa)
GUCY1A2guanylate cyclase 1, soluble, alpha 2; Has guanylyl cyclase on binding to the beta-1 subunit (732 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: medium (46%)