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STRINGSTRING
SIN3B SIN3B SIN3A SIN3A TAF1 TAF1 ZNF444 ZNF444 POTEE POTEE SMARCA4 SMARCA4 ZKSCAN3 ZKSCAN3 SMARCA2 SMARCA2 TAF1L TAF1L ZNF397 ZNF397 CCDC6 CCDC6 RIPK4 RIPK4 SCAND3 SCAND3 ZSCAN30 ZSCAN30 PPP2CB PPP2CB STRN4 STRN4 ZNF446 ZNF446 BCOR BCOR CAD CAD STRN3 STRN3 ZNF434 ZNF434 SCAND1 SCAND1 ZKSCAN4 ZKSCAN4 ZNF24 ZNF24 ZNF192 ZNF192 ZNF174 ZNF174
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme; PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (309 aa)
ZKSCAN3zinc finger with KRAB and SCAN domains 3; Transcriptional factor that binds to the consensus sequence 5’-[GT][AG][AGT]GGGG-3’ and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migation in various tumors and myelomas (538 aa)
ZNF24zinc finger protein 24; Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5’-TCAT-3’ DNA sequence (By similarity). Has transcription repressor activity in vitro (368 aa)
CCDC6coiled-coil domain containing 6 (474 aa)
CADcarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) (2225 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2; Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chrom [...] (1590 aa)
ZNF174zinc finger protein 174; Transcriptional repressor (407 aa)
TAF1TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa (1893 aa)
SCAND1SCAN domain containing 1; May regulate transcriptional activity (179 aa)
ZNF434zinc finger protein 434; May be involved in transcriptional regulation (485 aa)
ZSCAN30zinc finger and SCAN domain containing 30; May be involved in transcriptional regulation (494 aa)
ZNF397zinc finger protein 397; Isoform 3 acts as a DNA-dependent transcriptional repressor (534 aa)
RIPK4receptor-interacting serine-threonine kinase 4; Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation (784 aa)
ZNF192zinc finger protein 192; May be involved in transcriptional regulation (578 aa)
ZNF444zinc finger protein 444; Transcriptional regulator. Binds to the 5’-flanking critical region of the SCARF1 promoter (327 aa)
STRN3striatin, calmodulin binding protein 3; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein (797 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephos [...] (1679 aa)
SIN3ASIN3 transcription regulator homolog A (yeast); Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA (By similarity). Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation (1273 aa)
ZKSCAN4zinc finger with KRAB and SCAN domains 4; May be involved in the transcriptional activation of MDM2 and EP300 genes (545 aa)
BCORBCL6 corepressor (1755 aa)
SIN3BSIN3 transcription regulator homolog B (yeast); Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription (By similarity) (1162 aa)
STRN4striatin, calmodulin binding protein 4; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein (760 aa)
SCAND3SCAN domain containing 3 (1325 aa)
TAF1LTAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like; May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced (1826 aa)
POTEEPOTE ankyrin domain family member E (1075 aa)
ZNF446zinc finger protein 446; May be involved in transcriptional regulation (450 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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