Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain (296 aa) | ||
 | HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 (255 aa) | ||
 | UBC | ubiquitin C (685 aa) | ||
 | HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 (266 aa) | ||
 | HLA-G | major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells (338 aa) | ||
 | IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either ’Lys-63’- linked or linear polyubiquitin) and its functional importance is reported conflictingly. Als [...] (487 aa) | ||
 | HLA-DRB5 | major histocompatibility complex, class II, DR beta 5 (266 aa) | ||
 | HLA-C | major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity) (366 aa) | ||
 | HLA-A | major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity) (365 aa) | ||
 | HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 (261 aa) | ||
 | HLA-DOB | major histocompatibility complex, class II, DO beta (273 aa) | ||
 | HLA-DQB2 | major histocompatibility complex, class II, DQ beta 2 (227 aa) | ||
 | HLA-DPB1 | major histocompatibility complex, class II, DP beta 1 (258 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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