node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARL1 | UBC | ENSP00000261636 | ENSP00000344818 | ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus | ubiquitin C | 0.725 |
ARL16 | UBC | ENSP00000380635 | ENSP00000344818 | ADP-ribosylation factor-like 16 | ubiquitin C | 0.424 |
COPG1 | RAB19 | ENSP00000325002 | ENSP00000348778 | coatomer protein complex, subunit gamma 1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; t [...] | RAB19, member RAS oncogene family | 0.505 |
COPG1 | RAB1A | ENSP00000325002 | ENSP00000387286 | coatomer protein complex, subunit gamma 1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; t [...] | RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity | 0.569 |
COPG1 | RAB1B | ENSP00000325002 | ENSP00000310226 | coatomer protein complex, subunit gamma 1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; t [...] | RAB1B, member RAS oncogene family; Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments | 0.590 |
COPG1 | RAB33A | ENSP00000325002 | ENSP00000257017 | coatomer protein complex, subunit gamma 1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; t [...] | RAB33A, member RAS oncogene family | 0.542 |
COPG1 | RAB33B | ENSP00000325002 | ENSP00000306496 | coatomer protein complex, subunit gamma 1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; t [...] | RAB33B, member RAS oncogene family; Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. It is involved in autophagy, acting as a modulator of autophagosome formation | 0.505 |
COPG1 | RAB43 | ENSP00000325002 | ENSP00000319781 | coatomer protein complex, subunit gamma 1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; t [...] | RAB43, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport o [...] | 0.505 |
COPG1 | RABL6 | ENSP00000325002 | ENSP00000360727 | coatomer protein complex, subunit gamma 1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; t [...] | RAB, member RAS oncogene family-like 6 | 0.505 |
COPG1 | SEC22A | ENSP00000325002 | ENSP00000310521 | coatomer protein complex, subunit gamma 1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; t [...] | SEC22 vesicle trafficking protein homolog A (S. cerevisiae); May be involved in vesicle transport between the ER and the Golgi complex (By similarity) | 0.760 |
COPG1 | SEC22C | ENSP00000325002 | ENSP00000264454 | coatomer protein complex, subunit gamma 1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; t [...] | SEC22 vesicle trafficking protein homolog C (S. cerevisiae); May be involved in vesicle transport between the ER and the Golgi complex | 0.760 |
COPG1 | UBC | ENSP00000325002 | ENSP00000344818 | coatomer protein complex, subunit gamma 1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; t [...] | ubiquitin C | 0.964 |
COPG2 | RAB19 | ENSP00000393912 | ENSP00000348778 | coatomer protein complex, subunit gamma 2 | RAB19, member RAS oncogene family | 0.505 |
COPG2 | RAB1A | ENSP00000393912 | ENSP00000387286 | coatomer protein complex, subunit gamma 2 | RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity | 0.541 |
COPG2 | RAB1B | ENSP00000393912 | ENSP00000310226 | coatomer protein complex, subunit gamma 2 | RAB1B, member RAS oncogene family; Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments | 0.541 |
COPG2 | RAB33A | ENSP00000393912 | ENSP00000257017 | coatomer protein complex, subunit gamma 2 | RAB33A, member RAS oncogene family | 0.505 |
COPG2 | RAB33B | ENSP00000393912 | ENSP00000306496 | coatomer protein complex, subunit gamma 2 | RAB33B, member RAS oncogene family; Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. It is involved in autophagy, acting as a modulator of autophagosome formation | 0.505 |
COPG2 | RAB43 | ENSP00000393912 | ENSP00000319781 | coatomer protein complex, subunit gamma 2 | RAB43, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport o [...] | 0.505 |
COPG2 | RABL6 | ENSP00000393912 | ENSP00000360727 | coatomer protein complex, subunit gamma 2 | RAB, member RAS oncogene family-like 6 | 0.505 |
COPG2 | SEC22A | ENSP00000393912 | ENSP00000310521 | coatomer protein complex, subunit gamma 2 | SEC22 vesicle trafficking protein homolog A (S. cerevisiae); May be involved in vesicle transport between the ER and the Golgi complex (By similarity) | 0.760 |