node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B2M | HLA-C | ENSP00000452780 | ENSP00000365402 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity) | 0.986 |
B2M | HLA-G | ENSP00000452780 | ENSP00000353472 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells | 0.924 |
B2M | KIR2DL4 | ENSP00000452780 | ENSP00000339634 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 | 0.900 |
B2M | UBC | ENSP00000452780 | ENSP00000344818 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | ubiquitin C | 0.790 |
FCER1G | KIR2DL4 | ENSP00000289902 | ENSP00000339634 | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide; Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 | 0.613 |
FCER1G | PTPN11 | ENSP00000289902 | ENSP00000340944 | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide; Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | 0.910 |
HLA-C | B2M | ENSP00000365402 | ENSP00000452780 | major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity) | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | 0.986 |
HLA-C | HLA-G | ENSP00000365402 | ENSP00000353472 | major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity) | major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells | 0.545 |
HLA-C | KIR2DL4 | ENSP00000365402 | ENSP00000339634 | major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity) | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 | 0.804 |
HLA-C | UBC | ENSP00000365402 | ENSP00000344818 | major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity) | ubiquitin C | 0.987 |
HLA-G | B2M | ENSP00000353472 | ENSP00000452780 | major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | 0.924 |
HLA-G | HLA-C | ENSP00000353472 | ENSP00000365402 | major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells | major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity) | 0.545 |
HLA-G | KIR2DL4 | ENSP00000353472 | ENSP00000339634 | major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 | 0.613 |
KIR2DL4 | B2M | ENSP00000339634 | ENSP00000452780 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | 0.900 |
KIR2DL4 | FCER1G | ENSP00000339634 | ENSP00000289902 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide; Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin | 0.613 |
KIR2DL4 | HLA-C | ENSP00000339634 | ENSP00000365402 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 | major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity) | 0.804 |
KIR2DL4 | HLA-G | ENSP00000339634 | ENSP00000353472 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 | major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells | 0.613 |
KIR2DL4 | PTPN11 | ENSP00000339634 | ENSP00000340944 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | 0.810 |
KIR2DL4 | RNF216 | ENSP00000339634 | ENSP00000374552 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 | ring finger protein 216; Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down- regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3/ZIN inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis | 0.576 |
KIR2DL4 | TRAF6 | ENSP00000339634 | ENSP00000337853 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 | TNF receptor-associated factor 6, E3 ubiquitin protein ligase; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of ’Lys-63’-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF- kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Ad [...] | 0.576 |