node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HMGB1 | RASSF4 | ENSP00000343040 | ENSP00000339692 | high mobility group box 1; DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity) | Ras association (RalGDS/AF-6) domain family member 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest | 0.457 |
MST1 | RASSF2 | ENSP00000414287 | ENSP00000368684 | macrophage stimulating 1 (hepatocyte growth factor-like) | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | 0.999 |
MST1 | RASSF3 | ENSP00000414287 | ENSP00000336616 | macrophage stimulating 1 (hepatocyte growth factor-like) | Ras association (RalGDS/AF-6) domain family member 3 | 0.933 |
MST1 | RASSF4 | ENSP00000414287 | ENSP00000339692 | macrophage stimulating 1 (hepatocyte growth factor-like) | Ras association (RalGDS/AF-6) domain family member 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest | 0.999 |
MST1 | SAV1 | ENSP00000414287 | ENSP00000324729 | macrophage stimulating 1 (hepatocyte growth factor-like) | salvador homolog 1 (Drosophila); Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the n [...] | 0.999 |
MST1 | STK3 | ENSP00000414287 | ENSP00000390500 | macrophage stimulating 1 (hepatocyte growth factor-like) | serine/threonine kinase 3; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | 0.986 |
MST1 | STK4 | ENSP00000414287 | ENSP00000361892 | macrophage stimulating 1 (hepatocyte growth factor-like) | serine/threonine kinase 4; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | 0.999 |
RASSF2 | MST1 | ENSP00000368684 | ENSP00000414287 | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | macrophage stimulating 1 (hepatocyte growth factor-like) | 0.999 |
RASSF2 | RASSF3 | ENSP00000368684 | ENSP00000336616 | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | Ras association (RalGDS/AF-6) domain family member 3 | 0.567 |
RASSF2 | SAV1 | ENSP00000368684 | ENSP00000324729 | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | salvador homolog 1 (Drosophila); Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the n [...] | 0.422 |
RASSF2 | STK3 | ENSP00000368684 | ENSP00000390500 | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | serine/threonine kinase 3; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | 0.997 |
RASSF2 | STK4 | ENSP00000368684 | ENSP00000361892 | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | serine/threonine kinase 4; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | 0.999 |
RASSF3 | MST1 | ENSP00000336616 | ENSP00000414287 | Ras association (RalGDS/AF-6) domain family member 3 | macrophage stimulating 1 (hepatocyte growth factor-like) | 0.933 |
RASSF3 | RASSF2 | ENSP00000336616 | ENSP00000368684 | Ras association (RalGDS/AF-6) domain family member 3 | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | 0.567 |
RASSF3 | RASSF4 | ENSP00000336616 | ENSP00000339692 | Ras association (RalGDS/AF-6) domain family member 3 | Ras association (RalGDS/AF-6) domain family member 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest | 0.575 |
RASSF3 | SAV1 | ENSP00000336616 | ENSP00000324729 | Ras association (RalGDS/AF-6) domain family member 3 | salvador homolog 1 (Drosophila); Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the n [...] | 0.712 |
RASSF3 | STK3 | ENSP00000336616 | ENSP00000390500 | Ras association (RalGDS/AF-6) domain family member 3 | serine/threonine kinase 3; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | 0.979 |
RASSF3 | STK4 | ENSP00000336616 | ENSP00000361892 | Ras association (RalGDS/AF-6) domain family member 3 | serine/threonine kinase 4; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | 0.999 |
RASSF4 | HMGB1 | ENSP00000339692 | ENSP00000343040 | Ras association (RalGDS/AF-6) domain family member 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest | high mobility group box 1; DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity) | 0.457 |
RASSF4 | MST1 | ENSP00000339692 | ENSP00000414287 | Ras association (RalGDS/AF-6) domain family member 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest | macrophage stimulating 1 (hepatocyte growth factor-like) | 0.999 |