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RPL10L RPL10L MRPS2 MRPS2 MRPL33 MRPL33 MRPL17 MRPL17 MRPL13 MRPL13 MRPL19 MRPL19 MRPL27 MRPL27 MRPL22 MRPL22 MRPL36 MRPL36 MRPL46 MRPL46 MRPL32 MRPL32 MRPL15 MRPL15 MRPL41 MRPL41 MRPL16 MRPL16 MRPL49 MRPL49 MRPL23 MRPL23 MRPL40 MRPL40 LAMTOR3 LAMTOR3 MRPL47 MRPL47 MRPL34 MRPL34 MRPL43 MRPL43 NDUFA2 NDUFA2 FXR2 FXR2 DDX21 DDX21 DDX56 DDX56 SRPK1 SRPK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
MRPL32mitochondrial ribosomal protein L32 (188 aa)
MRPL27mitochondrial ribosomal protein L27 (148 aa)
MRPS2mitochondrial ribosomal protein S2 (296 aa)
FXR2fragile X mental retardation, autosomal homolog 2; RNA-binding protein (673 aa)
NDUFA2NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (99 aa)
MRPL34mitochondrial ribosomal protein L34 (92 aa)
DDX56DEAD (Asp-Glu-Ala-Asp) box helicase 56; May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity (547 aa)
MRPL15mitochondrial ribosomal protein L15 (296 aa)
MRPL49mitochondrial ribosomal protein L49 (166 aa)
MRPL17mitochondrial ribosomal protein L17 (175 aa)
MRPL33mitochondrial ribosomal protein L33 (65 aa)
RPL10Lribosomal protein L10-like; May play a role in compensating for the inactivated X- linked gene during spermatogenesis (214 aa)
MRPL16mitochondrial ribosomal protein L16; Component of the large subunit of mitochondrial ribosome (251 aa)
MRPL13mitochondrial ribosomal protein L13 (178 aa)
MRPL46mitochondrial ribosomal protein L46 (279 aa)
MRPL40mitochondrial ribosomal protein L40 (206 aa)
MRPL43mitochondrial ribosomal protein L43 (235 aa)
DDX21DEAD (Asp-Glu-Ala-Asp) box helicase 21; Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase). Functions as cofactor for JUN-activated transcription. Involved in rRNA processing (783 aa)
MRPL41mitochondrial ribosomal protein L41; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (137 aa)
SRPK1SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...] (655 aa)
MRPL23mitochondrial ribosomal protein L23 (153 aa)
MRPL36mitochondrial ribosomal protein L36; Component of the large subunit of the mitochondrial ribosome (Potential) (103 aa)
MRPL19mitochondrial ribosomal protein L19 (292 aa)
MRPL47mitochondrial ribosomal protein L47 (250 aa)
LAMTOR3late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances th [...] (124 aa)
MRPL22mitochondrial ribosomal protein L22 (206 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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