node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGEF10 | CD2AP | ENSP00000340297 | ENSP00000352264 | Rho guanine nucleotide exchange factor (GEF) 10; May play a role in developmental myelination of peripheral nerves | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis | 0.414 |
ARHGEF10 | COPG1 | ENSP00000340297 | ENSP00000325002 | Rho guanine nucleotide exchange factor (GEF) 10; May play a role in developmental myelination of peripheral nerves | coatomer protein complex, subunit gamma 1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; t [...] | 0.410 |
ARHGEF10 | KIF3B | ENSP00000340297 | ENSP00000364864 | Rho guanine nucleotide exchange factor (GEF) 10; May play a role in developmental myelination of peripheral nerves | kinesin family member 3B; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity) | 0.916 |
ARHGEF10 | PSME4 | ENSP00000340297 | ENSP00000384211 | Rho guanine nucleotide exchange factor (GEF) 10; May play a role in developmental myelination of peripheral nerves | proteasome (prosome, macropain) activator subunit 4; Activates proteasomal cleavage of peptides in an energy- independent manner. May be involved in spermatogenesis. May be involved in DNA repair | 0.506 |
ARHGEF10 | RHOA | ENSP00000340297 | ENSP00000400175 | Rho guanine nucleotide exchange factor (GEF) 10; May play a role in developmental myelination of peripheral nerves | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.919 |
ARHGEF10 | SART3 | ENSP00000340297 | ENSP00000228284 | Rho guanine nucleotide exchange factor (GEF) 10; May play a role in developmental myelination of peripheral nerves | squamous cell carcinoma antigen recognized by T cells 3; Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication | 0.530 |
ARHGEF10 | WDR48 | ENSP00000340297 | ENSP00000307491 | Rho guanine nucleotide exchange factor (GEF) 10; May play a role in developmental myelination of peripheral nerves | WD repeat domain 48 | 0.487 |
CD2AP | ARHGEF10 | ENSP00000352264 | ENSP00000340297 | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis | Rho guanine nucleotide exchange factor (GEF) 10; May play a role in developmental myelination of peripheral nerves | 0.414 |
CD2AP | LAMB2 | ENSP00000352264 | ENSP00000307156 | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis | laminin, beta 2 (laminin S); Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | 0.743 |
CD2AP | UBC | ENSP00000352264 | ENSP00000344818 | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis | ubiquitin C | 0.866 |
COPG1 | ARHGEF10 | ENSP00000325002 | ENSP00000340297 | coatomer protein complex, subunit gamma 1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; t [...] | Rho guanine nucleotide exchange factor (GEF) 10; May play a role in developmental myelination of peripheral nerves | 0.410 |
COPG1 | UBC | ENSP00000325002 | ENSP00000344818 | coatomer protein complex, subunit gamma 1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; t [...] | ubiquitin C | 0.964 |
KIF3B | ARHGEF10 | ENSP00000364864 | ENSP00000340297 | kinesin family member 3B; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity) | Rho guanine nucleotide exchange factor (GEF) 10; May play a role in developmental myelination of peripheral nerves | 0.916 |
KIF3B | UBC | ENSP00000364864 | ENSP00000344818 | kinesin family member 3B; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity) | ubiquitin C | 0.541 |
LAMB1 | LAMB2 | ENSP00000222399 | ENSP00000307156 | laminin, beta 1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | laminin, beta 2 (laminin S); Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | 0.909 |
LAMB1 | UBC | ENSP00000222399 | ENSP00000344818 | laminin, beta 1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | ubiquitin C | 0.828 |
LAMB2 | CD2AP | ENSP00000307156 | ENSP00000352264 | laminin, beta 2 (laminin S); Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis | 0.743 |
LAMB2 | LAMB1 | ENSP00000307156 | ENSP00000222399 | laminin, beta 2 (laminin S); Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | laminin, beta 1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | 0.909 |
LAMB2 | UBC | ENSP00000307156 | ENSP00000344818 | laminin, beta 2 (laminin S); Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | ubiquitin C | 0.800 |
PSME4 | ARHGEF10 | ENSP00000384211 | ENSP00000340297 | proteasome (prosome, macropain) activator subunit 4; Activates proteasomal cleavage of peptides in an energy- independent manner. May be involved in spermatogenesis. May be involved in DNA repair | Rho guanine nucleotide exchange factor (GEF) 10; May play a role in developmental myelination of peripheral nerves | 0.506 |