Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | RALBP1 | ralA binding protein 1; Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off [...] (655 aa) | ||
 | VIM | vimentin (466 aa) | ||
 | CASP6 | caspase 6, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death (293 aa) | ||
 | AKT1 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] (480 aa) | ||
 | WRAP73 | WD repeat containing, antisense to TP73 (460 aa) | ||
 | ZSCAN1 | zinc finger and SCAN domain containing 1; May be involved in transcriptional regulation (408 aa) | ||
 | KRT8 | keratin 8 (483 aa) | ||
 | TSC22D4 | TSC22 domain family, member 4; Transcriptional repressor (395 aa) | ||
 | EVPL | envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments (2033 aa) | ||
 | BDKRB2 | bradykinin receptor B2; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (391 aa) | ||
 | ALAS1 | aminolevulinate, delta-, synthase 1 (640 aa) | ||
 | EZR | ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (586 aa) | ||
 | PPL | periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling (1756 aa) | ||
 | COL17A1 | collagen, type XVII, alpha 1; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane (1497 aa) | ||
 | USP7 | ubiquitin specific peptidase 7 (herpes virus-associated); Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53- dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen pero [...] (1102 aa) | ||
 | UBC | ubiquitin C (685 aa) | ||
 | HTT | huntingtin; May play a role in microtubule-mediated transport or vesicle function (3142 aa) | ||
 | CEP57L1 | centrosomal protein 57kDa-like 1; Centrosomal protein which may be required for microtubule attachment to centrosomes (By similarity) (460 aa) | ||
 | ANXA9 | annexin A9; Low affinity receptor for acetylcholine known to be targeted by disease-causing pemphigus vulgaris antibodies in keratinocytes (345 aa) | ||
 | AHCYL1 | adenosylhomocysteinase-like 1 (530 aa) | ||
 | KAZN | kazrin, periplakin interacting protein (775 aa) | ||
 | BFSP1 | beaded filament structural protein 1, filensin (665 aa) | ||
 | ITSN1 | intersectin 1 (SH3 domain protein); Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1 (1721 aa) | ||
 | PPHLN1 | periphilin 1; Involved in epithelial differentiation and contributes to epidermal integrity and barrier formation (458 aa) | ||
 | OPRM1 | opioid receptor, mu 1 (493 aa) | ||
 | RAB3IP | RAB3A interacting protein (rabin3) (476 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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