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ADAM9 ADAM9 LAMB3 LAMB3 CD151 CD151 ADAM10 ADAM10 ITGB4 ITGB4 COL17A1 COL17A1 COL4A5 COL4A5 COL24A1 COL24A1 COL5A3 COL5A3 COL21A1 COL21A1 COL5A2 COL5A2 COL3A1 COL3A1 COL11A1 COL11A1 COL27A1 COL27A1 COL9A1 COL9A1 COL4A6 COL4A6 COL6A1 COL6A1 COL20A1 COL20A1 COL16A1 COL16A1 COL5A1 COL5A1 COL15A1 COL15A1 COL8A1 COL8A1 COL23A1 COL23A1 COL25A1 COL25A1 COL19A1 COL19A1 COL9A2 COL9A2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
ITGB4integrin, beta 4; Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility (1822 aa)
COL21A1collagen, type XXI, alpha 1 (957 aa)
ADAM10ADAM metallopeptidase domain 10; Cleaves the membrane-bound precursor of TNF-alpha at ’76-Ala-|-Val-77’ to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth- like factor, ephrin-A2 and for constitutive and regulated alpha- secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the [...] (748 aa)
COL8A1collagen, type VIII, alpha 1; Macromolecular component of the subendothelium. Major component of the Descemet’s membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (744 aa)
COL5A3collagen, type V, alpha 3; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (1745 aa)
COL3A1collagen, type III, alpha 1 (1466 aa)
COL19A1collagen, type XIX, alpha 1 (1142 aa)
CD151CD151 molecule (Raph blood group); Essential for the proper assembly of the glomerular and tubular basement membranes in kidney (253 aa)
COL4A5collagen, type IV, alpha 5; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen (1691 aa)
COL17A1collagen, type XVII, alpha 1; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane (1497 aa)
LAMB3laminin, beta 3; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components (1172 aa)
COL27A1collagen, type XXVII, alpha 1; Plays a role during the calcification of cartilage and the transition of cartilage to bone (1860 aa)
COL9A1collagen, type IX, alpha 1 (921 aa)
COL20A1collagen, type XX, alpha 1; Probable collagen protein (1284 aa)
COL6A1collagen, type VI, alpha 1; Collagen VI acts as a cell-binding protein (1028 aa)
COL11A1collagen, type XI, alpha 1 (1806 aa)
COL24A1collagen, type XXIV, alpha 1; May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development (1714 aa)
COL5A1collagen, type V, alpha 1; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (1838 aa)
COL4A6collagen, type IV, alpha 6 (1691 aa)
COL9A2collagen, type IX, alpha 2; Structural component of hyaline cartilage and vitreous of the eye (689 aa)
COL16A1collagen, type XVI, alpha 1; Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology (1604 aa)
COL5A2collagen, type V, alpha 2 (1499 aa)
COL15A1collagen, type XV, alpha 1; Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle (1388 aa)
COL23A1collagen, type XXIII, alpha 1 (540 aa)
COL25A1collagen, type XXV, alpha 1; Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin (654 aa)
ADAM9ADAM metallopeptidase domain 9; Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP (819 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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