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ENSG00000064489 ENSG00000064489 STMN2 STMN2 CCDC11 CCDC11 C10orf82 C10orf82 COL20A1 COL20A1 DUSP21 DUSP21 MEF2BNB MEF2BNB SMC3 SMC3 CDKN1A CDKN1A HYI HYI SNX7 SNX7 MEF2B MEF2B TEX11 TEX11 TBC1D22B TBC1D22B PSENEN PSENEN VIL1 VIL1 CXCL14 CXCL14 TIPIN TIPIN DUSP6 DUSP6 ING3 ING3 LIN37 LIN37 MYEF2 MYEF2 FAM156A FAM156A EFHC1 EFHC1 BEX1 BEX1 ZNF414 ZNF414
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining
coexpression edge
co-expression
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MEF2Bmyocyte enhancer factor 2B; Transcriptional activator which binds specifically to the MEF2 element, 5’-YTA[AT](4)TAR-3’, found in numerous muscle- specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription (368 aa)
PSENENpresenilin enhancer 2 homolog (C. elegans); Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity (101 aa)
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (164 aa)
VIL1villin 1; Epithelial cell-specific Ca(2+)-regulated actin- modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the int [...] (827 aa)
TIPINTIMELESS interacting protein; Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (301 aa)
DUSP6dual specificity phosphatase 6; Inactivates MAP kinases. Has a specificity for the ERK family (381 aa)
LIN37lin-37 homolog (C. elegans) (246 aa)
SNX7sorting nexin 7 (451 aa)
MYEF2myelin expression factor 2 (600 aa)
FAM156Afamily with sequence similarity 156, member A (213 aa)
ING3inhibitor of growth family, member 3 (418 aa)
CXCL14chemokine (C-X-C motif) ligand 14; Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays (111 aa)
TEX11testis expressed 11; Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers (By similarity) (940 aa)
DUSP21dual specificity phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine (190 aa)
COL20A1collagen, type XX, alpha 1; Probable collagen protein (1284 aa)
SMC3structural maintenance of chromosomes 3; Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement (1217 aa)
C10orf82chromosome 10 open reading frame 82 (154 aa)
EFHC1EF-hand domain (C-terminal) containing 1; May enhance calcium influx through CACNA1E and stimulate programmed cell death (640 aa)
HYIhydroxypyruvate isomerase (putative); Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) (277 aa)
BEX1brain expressed, X-linked 1; Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity) (125 aa)
TBC1D22BTBC1 domain family, member 22B; May act as a GTPase-activating protein for Rab family protein(s) (By similarity) (505 aa)
ZNF414zinc finger protein 414; May be involved in transcriptional regulation (390 aa)
CCDC11coiled-coil domain containing 11 (514 aa)
MEF2BNBMEF2B neighbor (119 aa)
STMN2stathmin-like 2; Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity) (187 aa)
ENSG00000064489MEF2BNB-MEF2B readthrough (119 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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