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STRINGSTRING
TTF2 TTF2 HNRNPA1 HNRNPA1 CDC42EP2 CDC42EP2 CDC42EP3 CDC42EP3 S100A4 S100A4 GAS7 GAS7 UBC UBC BRSK2 BRSK2 SEPT6 SEPT6 IFNGR1 IFNGR1 SEPT7 SEPT7 SEPT8 SEPT8 SEPT12 SEPT12 SEPT4 SEPT4 SEPT9 SEPT9 SEPT3 SEPT3 SEPT2 SEPT2 SOCS7 SOCS7 SEPT1 SEPT1 SEPT5 SEPT5 SEPT10 SEPT10 BRSK1 BRSK1 SEPT11 SEPT11 CCBL2 CCBL2 SEPT14 SEPT14 CCBL1 CCBL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CCBL2cysteine conjugate-beta lyase 2 (454 aa)
SEPT11septin 11; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy (429 aa)
SEPT12septin 12; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) (358 aa)
CDC42EP2CDC42 effector protein (Rho GTPase binding) 2; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (210 aa)
CDC42EP3CDC42 effector protein (Rho GTPase binding) 3; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts (254 aa)
CCBL1cysteine conjugate-beta lyase, cytoplasmic; Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (422 aa)
BRSK1BR serine/threonine kinase 1; Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in post-mitotic neurons, leading to down-regulate WEE1 activit [...] (778 aa)
BRSK2BR serine/threonine kinase 2; Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in post-mitotic neurons, leading to down-regu [...] (668 aa)
SEPT4septin 4; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli (478 aa)
SEPT6septin 6; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication (434 aa)
HNRNPA1heterogeneous nuclear ribonucleoprotein A1; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication (372 aa)
UBCubiquitin C (685 aa)
S100A4S100 calcium binding protein A4 (101 aa)
SEPT2septin 2; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongat [...] (361 aa)
IFNGR1interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer (489 aa)
TTF2transcription termination factor, RNA polymerase II; DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing (1162 aa)
SEPT8septin 8; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (483 aa)
SEPT14septin 14; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) (432 aa)
SEPT3septin 3; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) (358 aa)
SEPT10septin 10; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential) (454 aa)
SEPT7septin 7; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements (438 aa)
SEPT9septin 9 (586 aa)
SEPT5septin 5; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity) (369 aa)
GAS7growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons (476 aa)
SEPT1septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) (367 aa)
SOCS7suppressor of cytokine signaling 7; Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF- like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of t [...] (581 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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