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STRINGSTRING
PRKDC PRKDC THOC2 THOC2 MDM2 MDM2 THYN1 THYN1 UBC UBC TFAP4 TFAP4 GOLGA2 GOLGA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
TFAP4transcription factor AP-4 (activating enhancer binding protein 4); Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5’- CAGCTG-3’ (338 aa)
THOC2THO complex 2; Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex [...] (1593 aa)
PRKDCprotein kinase, DNA-activated, catalytic polypeptide (4127 aa)
THYN1thymocyte nuclear protein 1 (225 aa)
UBCubiquitin C (685 aa)
GOLGA2golgin A2; Golgi auto-antigen; probably involved in maintaining cis-Golgi structure (1002 aa)
MDM2Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) (497 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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