node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACVR2A | ENG | ENSP00000241416 | ENSP00000362299 | activin A receptor, type IIA; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A | endoglin; Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors | 0.925 |
ACVR2A | TCTEX1D4 | ENSP00000241416 | ENSP00000341803 | activin A receptor, type IIA; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A | Tctex1 domain containing 4 | 0.564 |
ACVR2A | TGFBR3 | ENSP00000241416 | ENSP00000212355 | activin A receptor, type IIA; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A | transforming growth factor, beta receptor III; Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors | 0.926 |
DNAI2 | DYNLT1 | ENSP00000308312 | ENSP00000356056 | dynein, axonemal, intermediate chain 2; Part of the dynein complex of respiratory cilia | dynein, light chain, Tctex-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic [...] | 0.762 |
DNAI2 | DYNLT3 | ENSP00000308312 | ENSP00000367841 | dynein, axonemal, intermediate chain 2; Part of the dynein complex of respiratory cilia | dynein, light chain, Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity) | 0.732 |
DNAI2 | TCTEX1D4 | ENSP00000308312 | ENSP00000341803 | dynein, axonemal, intermediate chain 2; Part of the dynein complex of respiratory cilia | Tctex1 domain containing 4 | 0.560 |
DYNLT1 | DNAI2 | ENSP00000356056 | ENSP00000308312 | dynein, light chain, Tctex-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic [...] | dynein, axonemal, intermediate chain 2; Part of the dynein complex of respiratory cilia | 0.762 |
DYNLT1 | DYNLT3 | ENSP00000356056 | ENSP00000367841 | dynein, light chain, Tctex-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic [...] | dynein, light chain, Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity) | 0.727 |
DYNLT1 | TCTEX1D4 | ENSP00000356056 | ENSP00000341803 | dynein, light chain, Tctex-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic [...] | Tctex1 domain containing 4 | 0.868 |
DYNLT3 | DNAI2 | ENSP00000367841 | ENSP00000308312 | dynein, light chain, Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity) | dynein, axonemal, intermediate chain 2; Part of the dynein complex of respiratory cilia | 0.732 |
DYNLT3 | DYNLT1 | ENSP00000367841 | ENSP00000356056 | dynein, light chain, Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity) | dynein, light chain, Tctex-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic [...] | 0.727 |
DYNLT3 | TCTEX1D4 | ENSP00000367841 | ENSP00000341803 | dynein, light chain, Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity) | Tctex1 domain containing 4 | 0.729 |
ENG | ACVR2A | ENSP00000362299 | ENSP00000241416 | endoglin; Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors | activin A receptor, type IIA; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A | 0.925 |
ENG | TCTEX1D4 | ENSP00000362299 | ENSP00000341803 | endoglin; Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors | Tctex1 domain containing 4 | 0.573 |
ENG | TGFBR2 | ENSP00000362299 | ENSP00000351905 | endoglin; Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors | transforming growth factor, beta receptor II (70/80kDa); Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, i [...] | 0.975 |
ENG | TGFBR3 | ENSP00000362299 | ENSP00000212355 | endoglin; Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors | transforming growth factor, beta receptor III; Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors | 0.582 |
PPP1CC | TGFBR2 | ENSP00000335084 | ENSP00000351905 | protein phosphatase 1, catalytic subunit, gamma isozyme; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- associated Ca [...] | transforming growth factor, beta receptor II (70/80kDa); Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, i [...] | 0.913 |
TCTEX1D4 | ACVR2A | ENSP00000341803 | ENSP00000241416 | Tctex1 domain containing 4 | activin A receptor, type IIA; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A | 0.564 |
TCTEX1D4 | DNAI2 | ENSP00000341803 | ENSP00000308312 | Tctex1 domain containing 4 | dynein, axonemal, intermediate chain 2; Part of the dynein complex of respiratory cilia | 0.560 |
TCTEX1D4 | DYNLT1 | ENSP00000341803 | ENSP00000356056 | Tctex1 domain containing 4 | dynein, light chain, Tctex-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic [...] | 0.868 |