Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
DDX3Y DDX3Y RFPL4A RFPL4A DDX4 DDX4 TRIM4 TRIM4 TRIM60 TRIM60 SP140 SP140 TRIM66 TRIM66 NANOS3 NANOS3 PUM1 PUM1 PUM2 PUM2 TRIML1 TRIML1 RNF186 RNF186 EZH1 EZH1 LOC729974 LOC729974 TRIM31 TRIM31 DDX3X DDX3X ENSG00000258588 ENSG00000258588 EZH2 EZH2 TRIM68 TRIM68 RFPL3 RFPL3 SETD7 SETD7 TRIM64B TRIM64B XRN1 XRN1 TRIM10 TRIM10 RNF112 RNF112 TRIM51 TRIM51
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
RFPL3ret finger protein-like 3 (317 aa)
XRN15’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) (1706 aa)
SETD7SET domain containing (lysine methyltransferase) 7; Histone methyltransferase that specifically monomethylates ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylat [...] (366 aa)
TRIM68tripartite motif containing 68 (485 aa)
EZH2enhancer of zeste homolog 2 (Drosophila) (751 aa)
TRIML1tripartite motif family-like 1; Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development (By similarity) (468 aa)
TRIM64Btripartite motif containing 64B (449 aa)
DDX3YDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked; Probable ATP-dependent RNA helicase. May play a role in spermatogenesis (660 aa)
PUM2pumilio homolog 2 (Drosophila); Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3’-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts (1064 aa)
NANOS3nanos homolog 3 (Drosophila); Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax- dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis (192 aa)
TRIM60tripartite motif containing 60 (471 aa)
LOC729974Uncharacterized protein (287 aa)
ENSG00000258588TRIM6-TRIM34 readthrough (842 aa)
TRIM4tripartite motif containing 4 (500 aa)
RNF186ring finger protein 186 (227 aa)
TRIM31tripartite motif containing 31 (425 aa)
SP140SP140 nuclear body protein; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (867 aa)
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double stranded DNA with a preference for 5’- single stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can [...] (662 aa)
TRIM66tripartite motif containing 66; May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity) (1245 aa)
PUM1pumilio homolog 1 (Drosophila); Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3’-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity) (1188 aa)
RFPL4Aret finger protein-like 4A (287 aa)
TRIM51tripartite motif-containing 51 (452 aa)
TRIM10tripartite motif containing 10 (481 aa)
EZH1enhancer of zeste homolog 1 (Drosophila) (747 aa)
DDX4DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; May play a role in germ cell development. May play a role in sperm motility (724 aa)
RNF112ring finger protein 112 (631 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (25%)