node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARG1 | ASS1 | ENSP00000357066 | ENSP00000253004 | arginase, liver | argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity) | 0.651 |
ARG1 | OTC | ENSP00000357066 | ENSP00000039007 | arginase, liver | ornithine carbamoyltransferase | 0.981 |
ARG1 | SLC25A15 | ENSP00000357066 | ENSP00000342267 | arginase, liver | solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15; Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix | 0.906 |
ARG1 | UBC | ENSP00000357066 | ENSP00000344818 | arginase, liver | ubiquitin C | 0.576 |
ASS1 | ARG1 | ENSP00000253004 | ENSP00000357066 | argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity) | arginase, liver | 0.651 |
ASS1 | OTC | ENSP00000253004 | ENSP00000039007 | argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity) | ornithine carbamoyltransferase | 0.998 |
ASS1 | SLC25A15 | ENSP00000253004 | ENSP00000342267 | argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity) | solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15; Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix | 0.961 |
ASS1 | UBC | ENSP00000253004 | ENSP00000344818 | argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity) | ubiquitin C | 0.890 |
CNOT7 | CNOT8 | ENSP00000355279 | ENSP00000285896 | CCR4-NOT transcription complex, subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translation [...] | CCR4-NOT transcription complex, subunit 8; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be [...] | 0.901 |
CNOT7 | ELAVL1 | ENSP00000355279 | ENSP00000385269 | CCR4-NOT transcription complex, subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translation [...] | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | 0.422 |
CNOT7 | UBC | ENSP00000355279 | ENSP00000344818 | CCR4-NOT transcription complex, subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translation [...] | ubiquitin C | 0.734 |
CNOT8 | CNOT7 | ENSP00000285896 | ENSP00000355279 | CCR4-NOT transcription complex, subunit 8; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be [...] | CCR4-NOT transcription complex, subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translation [...] | 0.901 |
CNOT8 | ELAVL1 | ENSP00000285896 | ENSP00000385269 | CCR4-NOT transcription complex, subunit 8; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be [...] | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | 0.454 |
CNOT8 | UBC | ENSP00000285896 | ENSP00000344818 | CCR4-NOT transcription complex, subunit 8; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be [...] | ubiquitin C | 0.898 |
ELAVL1 | CNOT7 | ENSP00000385269 | ENSP00000355279 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | CCR4-NOT transcription complex, subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translation [...] | 0.422 |
ELAVL1 | CNOT8 | ENSP00000385269 | ENSP00000285896 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | CCR4-NOT transcription complex, subunit 8; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be [...] | 0.454 |
ELAVL1 | UBC | ENSP00000385269 | ENSP00000344818 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | ubiquitin C | 0.998 |
OTC | ARG1 | ENSP00000039007 | ENSP00000357066 | ornithine carbamoyltransferase | arginase, liver | 0.981 |
OTC | ASS1 | ENSP00000039007 | ENSP00000253004 | ornithine carbamoyltransferase | argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity) | 0.998 |
OTC | SLC25A15 | ENSP00000039007 | ENSP00000342267 | ornithine carbamoyltransferase | solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15; Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix | 0.915 |