13 items (Homo sapiens) - STRING network view

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	KRT15	keratin 15 (456 aa)
	NUAK1	NUAK family, SNF1-like kinase, 1; Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of ’Ser-464’ of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1- phosphorylated P [...] (661 aa)
	USP53	ubiquitin specific peptidase 53; Has no peptidase activity (1073 aa)
	DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae); Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity) (259 aa)
	AP2M1	adaptor-related protein complex 2, mu 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a [...] (435 aa)
	CRK	v-crk sarcoma virus CT10 oncogene homolog (avian); The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling (304 aa)
	USP32	ubiquitin specific peptidase 32 (1604 aa)
	C12orf44	chromosome 12 open reading frame 44; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation (218 aa)
	KRT77	keratin 77 (578 aa)
	UBC	ubiquitin C (685 aa)
	NFKBIL1	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 (381 aa)
	LGR4	leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor (951 aa)
	SHC1	SHC (Src homology 2 domain containing) transforming protein 1 (584 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP2M1	KRT77	ENSP00000292807	ENSP00000342710	adaptor-related protein complex 2, mu 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a [...]	keratin 77	0.499
AP2M1	SHC1	ENSP00000292807	ENSP00000401303	adaptor-related protein complex 2, mu 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a [...]	SHC (Src homology 2 domain containing) transforming protein 1	0.631
AP2M1	UBC	ENSP00000292807	ENSP00000344818	adaptor-related protein complex 2, mu 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a [...]	ubiquitin C	0.979
C12orf44	UBC	ENSP00000338990	ENSP00000344818	chromosome 12 open reading frame 44; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation	ubiquitin C	0.721
CRK	SHC1	ENSP00000300574	ENSP00000401303	v-crk sarcoma virus CT10 oncogene homolog (avian); The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling	SHC (Src homology 2 domain containing) transforming protein 1	0.963
CRK	UBC	ENSP00000300574	ENSP00000344818	v-crk sarcoma virus CT10 oncogene homolog (avian); The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling	ubiquitin C	0.513
DCUN1D1	UBC	ENSP00000292782	ENSP00000344818	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae); Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity)	ubiquitin C	0.985
KRT15	UBC	ENSP00000254043	ENSP00000344818	keratin 15	ubiquitin C	0.806
KRT77	AP2M1	ENSP00000342710	ENSP00000292807	keratin 77	adaptor-related protein complex 2, mu 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a [...]	0.499
KRT77	UBC	ENSP00000342710	ENSP00000344818	keratin 77	ubiquitin C	0.856
KRT77	USP32	ENSP00000342710	ENSP00000300896	keratin 77	ubiquitin specific peptidase 32	0.740
KRT77	USP53	ENSP00000342710	ENSP00000274030	keratin 77	ubiquitin specific peptidase 53; Has no peptidase activity	0.740
LGR4	UBC	ENSP00000368516	ENSP00000344818	leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor	ubiquitin C	0.955
NUAK1	UBC	ENSP00000261402	ENSP00000344818	NUAK family, SNF1-like kinase, 1; Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of ’Ser-464’ of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1- phosphorylated P [...]	ubiquitin C	0.570
SHC1	AP2M1	ENSP00000401303	ENSP00000292807	SHC (Src homology 2 domain containing) transforming protein 1	adaptor-related protein complex 2, mu 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a [...]	0.631
SHC1	CRK	ENSP00000401303	ENSP00000300574	SHC (Src homology 2 domain containing) transforming protein 1	v-crk sarcoma virus CT10 oncogene homolog (avian); The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling	0.963
SHC1	UBC	ENSP00000401303	ENSP00000344818	SHC (Src homology 2 domain containing) transforming protein 1	ubiquitin C	0.850
UBC	AP2M1	ENSP00000344818	ENSP00000292807	ubiquitin C	adaptor-related protein complex 2, mu 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a [...]	0.979
UBC	C12orf44	ENSP00000344818	ENSP00000338990	ubiquitin C	chromosome 12 open reading frame 44; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation	0.721
UBC	CRK	ENSP00000344818	ENSP00000300574	ubiquitin C	v-crk sarcoma virus CT10 oncogene homolog (avian); The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling	0.513

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