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CT45A5 CT45A5 FBXO28 FBXO28 TIFA TIFA ZRSR2 ZRSR2 PTMS PTMS TM4SF1 TM4SF1 LGALS14 LGALS14 NFASC NFASC ZCCHC17 ZCCHC17 NPM2 NPM2 SDCBP SDCBP SDCBP2 SDCBP2 NRXN1 NRXN1 PRPF38A PRPF38A PRPF40A PRPF40A BEND7 BEND7 TNP1 TNP1 LYAR LYAR C1orf35 C1orf35 ARF4 ARF4 LGALS2 LGALS2 PAFAH1B3 PAFAH1B3 EIF1AD EIF1AD FAM133A FAM133A PRR13 PRR13 ADAP1 ADAP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
LGALS2lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known (132 aa)
TNP1transition protein 1 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins (55 aa)
PRPF38APRP38 pre-mRNA processing factor 38 (yeast) domain containing A; May be required for pre-mRNA splicing (Potential) (312 aa)
SDCBPsyndecan binding protein (syntenin); Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (298 aa)
PAFAH1B3platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa); Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain (231 aa)
ADAP1ArfGAP with dual PH domains 1; GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4) (374 aa)
C1orf35chromosome 1 open reading frame 35 (263 aa)
NPM2nucleophosmin/nucleoplasmin 2; Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization (214 aa)
ZRSR2zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2; Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3’-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP- dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing (482 aa)
TM4SF1transmembrane 4 L six family member 1 (202 aa)
ARF4ADP-ribosylation factor 4; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (180 aa)
EIF1ADeukaryotic translation initiation factor 1A domain containing; Plays a role into cellular response to oxidative stress. Decreases cell proliferation (165 aa)
PTMSparathymosin; Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections (102 aa)
FAM133Afamily with sequence similarity 133, member A (248 aa)
SDCBP2syndecan binding protein (syntenin) 2 (292 aa)
ZCCHC17zinc finger, CCHC domain containing 17 (241 aa)
NFASCneurofascin (1240 aa)
BEND7BEN domain containing 7 (468 aa)
LYARLy1 antibody reactive homolog (mouse) (379 aa)
LGALS14lectin, galactoside-binding, soluble, 14 (168 aa)
TIFATRAF-interacting protein with forkhead-associated domain; Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism (184 aa)
FBXO28F-box protein 28; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (By similarity) (368 aa)
CT45A5cancer/testis antigen family 45, member A5 (189 aa)
NRXN1neurexin 1; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity) (1547 aa)
PRPF40APRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae); Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing (930 aa)
PRR13proline rich 13; Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane- induced apoptosis (148 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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