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STRINGSTRING
PLAC9 PLAC9 HRAS HRAS NRAS NRAS RAP1B RAP1B RAP1A RAP1A RRAS RRAS RAPGEF5 RAPGEF5 RAP2B RAP2B VANGL1 VANGL1 MRAS MRAS RAP2A RAP2A KCND3 KCND3 TMEM253 TMEM253
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
RAP2ARAP2A, member of RAS oncogene family; Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading (183 aa)
RRASrelated RAS viral (r-ras) oncogene homolog; Regulates the organization of the actin cytoskeleton (218 aa)
RAP1BRAP1B, member of RAS oncogene family (184 aa)
MRASmuscle RAS oncogene homolog; May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway (208 aa)
HRASv-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (189 aa)
VANGL1vang-like 1 (van gogh, Drosophila) (524 aa)
RAP2BRAP2B, member of RAS oncogene family; Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells (183 aa)
KCND3potassium voltage-gated channel, Shal-related subfamily, member 3; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits (655 aa)
RAPGEF5Rap guanine nucleotide exchange factor (GEF) 5; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation (730 aa)
RAP1ARAP1A, member of RAS oncogene family; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner (184 aa)
NRASneuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (189 aa)
PLAC9placenta-specific 9 (97 aa)
TMEM253transmembrane protein 253 (217 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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