node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HRAS | NRAS | ENSP00000309845 | ENSP00000358548 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
HRAS | RAP1B | ENSP00000309845 | ENSP00000250559 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | RAP1B, member of RAS oncogene family | 0.597 |
HRAS | RAPGEF5 | ENSP00000309845 | ENSP00000343656 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | Rap guanine nucleotide exchange factor (GEF) 5; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation | 0.862 |
KCND3 | RAPGEF5 | ENSP00000319591 | ENSP00000343656 | potassium voltage-gated channel, Shal-related subfamily, member 3; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits | Rap guanine nucleotide exchange factor (GEF) 5; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation | 0.497 |
MRAS | RAPGEF5 | ENSP00000289104 | ENSP00000343656 | muscle RAS oncogene homolog; May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway | Rap guanine nucleotide exchange factor (GEF) 5; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation | 0.978 |
NRAS | HRAS | ENSP00000358548 | ENSP00000309845 | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
NRAS | RAPGEF5 | ENSP00000358548 | ENSP00000343656 | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | Rap guanine nucleotide exchange factor (GEF) 5; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation | 0.824 |
RAP1A | RAP1B | ENSP00000348786 | ENSP00000250559 | RAP1A, member of RAS oncogene family; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner | RAP1B, member of RAS oncogene family | 0.901 |
RAP1A | RAPGEF5 | ENSP00000348786 | ENSP00000343656 | RAP1A, member of RAS oncogene family; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner | Rap guanine nucleotide exchange factor (GEF) 5; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation | 0.983 |
RAP1A | RRAS | ENSP00000348786 | ENSP00000246792 | RAP1A, member of RAS oncogene family; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner | related RAS viral (r-ras) oncogene homolog; Regulates the organization of the actin cytoskeleton | 0.476 |
RAP1B | HRAS | ENSP00000250559 | ENSP00000309845 | RAP1B, member of RAS oncogene family | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.597 |
RAP1B | RAP1A | ENSP00000250559 | ENSP00000348786 | RAP1B, member of RAS oncogene family | RAP1A, member of RAS oncogene family; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner | 0.901 |
RAP1B | RAPGEF5 | ENSP00000250559 | ENSP00000343656 | RAP1B, member of RAS oncogene family | Rap guanine nucleotide exchange factor (GEF) 5; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation | 0.818 |
RAP1B | RRAS | ENSP00000250559 | ENSP00000246792 | RAP1B, member of RAS oncogene family | related RAS viral (r-ras) oncogene homolog; Regulates the organization of the actin cytoskeleton | 0.467 |
RAP2A | RAPGEF5 | ENSP00000245304 | ENSP00000343656 | RAP2A, member of RAS oncogene family; Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading | Rap guanine nucleotide exchange factor (GEF) 5; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation | 0.714 |
RAP2B | RAPGEF5 | ENSP00000319096 | ENSP00000343656 | RAP2B, member of RAS oncogene family; Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells | Rap guanine nucleotide exchange factor (GEF) 5; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation | 0.730 |
RAPGEF5 | HRAS | ENSP00000343656 | ENSP00000309845 | Rap guanine nucleotide exchange factor (GEF) 5; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.862 |
RAPGEF5 | KCND3 | ENSP00000343656 | ENSP00000319591 | Rap guanine nucleotide exchange factor (GEF) 5; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation | potassium voltage-gated channel, Shal-related subfamily, member 3; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits | 0.497 |
RAPGEF5 | MRAS | ENSP00000343656 | ENSP00000289104 | Rap guanine nucleotide exchange factor (GEF) 5; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation | muscle RAS oncogene homolog; May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway | 0.978 |
RAPGEF5 | NRAS | ENSP00000343656 | ENSP00000358548 | Rap guanine nucleotide exchange factor (GEF) 5; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.824 |