ALX homeobox 4; Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development

homeobox B13; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

ataxin 1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function

orthodenticle homeobox 2; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS)- 5’-TCTAATCCC-3’

cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...]

microphthalmia-associated transcription factor

diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity)

orthodenticle homeobox 2; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS)- 5’-TCTAATCCC-3’

forkhead box A2; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ’pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5’-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3’ (By similarity). In embryonic development is required for notochord formation. Involved in the devel [...]

LIM homeobox 1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis

forkhead box A2; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ’pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5’-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3’ (By similarity). In embryonic development is required for notochord formation. Involved in the devel [...]

Mix paired-like homeobox; Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity)

forkhead box A2; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ’pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5’-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3’ (By similarity). In embryonic development is required for notochord formation. Involved in the devel [...]

orthodenticle homeobox 2; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS)- 5’-TCTAATCCC-3’

homeobox B13; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

ALX homeobox 4; Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development

LIM homeobox 1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis

forkhead box A2; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ’pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5’-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3’ (By similarity). In embryonic development is required for notochord formation. Involved in the devel [...]

LIM homeobox 1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis

orthodenticle homeobox 2; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS)- 5’-TCTAATCCC-3’

microphthalmia-associated transcription factor

cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...]

microphthalmia-associated transcription factor

orthodenticle homeobox 2; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS)- 5’-TCTAATCCC-3’

Mix paired-like homeobox; Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity)

forkhead box A2; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ’pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5’-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3’ (By similarity). In embryonic development is required for notochord formation. Involved in the devel [...]

orthodenticle homeobox 2; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS)- 5’-TCTAATCCC-3’

ataxin 1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function

orthodenticle homeobox 2; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS)- 5’-TCTAATCCC-3’

diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity)

orthodenticle homeobox 2; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS)- 5’-TCTAATCCC-3’

forkhead box A2; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ’pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5’-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3’ (By similarity). In embryonic development is required for notochord formation. Involved in the devel [...]

orthodenticle homeobox 2; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS)- 5’-TCTAATCCC-3’

LIM homeobox 1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis

orthodenticle homeobox 2; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS)- 5’-TCTAATCCC-3’

microphthalmia-associated transcription factor

orthodenticle homeobox 2; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS)- 5’-TCTAATCCC-3’

transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)

transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)

orthodenticle homeobox 2; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS)- 5’-TCTAATCCC-3’