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B3GNT3 B3GNT3 B3GNT2 B3GNT2 B3GNT7 B3GNT7 CHST2 CHST2 B3GNT1 B3GNT1 KERA KERA CHST6 CHST6 SLC35D2 SLC35D2 LUM LUM OMD OMD ST3GAL2 ST3GAL2 OGN OGN ST3GAL6 ST3GAL6 FMOD FMOD B3GNT4 B3GNT4 CHST1 CHST1 PRELP PRELP ACAN ACAN ST3GAL4 ST3GAL4 ST3GAL1 ST3GAL1 HSPG2 HSPG2 ST3GAL3 ST3GAL3 CHST5 CHST5 NID2 NID2 FBLN2 FBLN2 NID1 NID1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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from curated databases
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experimentally determined
Predicted Interactions
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gene fusions
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gene co-occurrence
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NID2nidogen 2 (osteonidogen); Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions (1375 aa)
ST3GAL4ST3 beta-galactoside alpha-2,3-sialyltransferase 4; It may catalyze the formation of the NeuAc-alpha-2,3- Gal-beta-1,3-GalNAc- or NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant. Also acts on the corresponding 1,3- galactosyl derivative (329 aa)
SLC35D2solute carrier family 35, member D2; Antiporter transporting nucleotide sugars such as UDP-N- acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP- mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling (337 aa)
OGNosteoglycin; Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2 (298 aa)
ST3GAL3ST3 beta-galactoside alpha-2,3-sialyltransferase 3 (444 aa)
NID1nidogen 1; Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions (1247 aa)
LUMlumican (338 aa)
KERAkeratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix (352 aa)
B3GNT7UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 7; May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratan sulfate-related glycans. May play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues (401 aa)
B3GNT2UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 2; Catalyzes the initiation and elongation of poly-N- acetyllactosamine chains (397 aa)
CHST2carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymp [...] (530 aa)
B3GNT1UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 1; Can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans (415 aa)
CHST1carbohydrate (keratan sulfate Gal-6) sulfotransferase 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N- acetyllactosamine oligosaccharide chains att [...] (411 aa)
ST3GAL1ST3 beta-galactoside alpha-2,3-sialyltransferase 1; It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O- linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values (340 aa)
B3GNT4UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 4; Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides (378 aa)
B3GNT3UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 3; Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides (372 aa)
CHST6carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the non-reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N- acetyllactosamine structures (395 aa)
CHST5carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substra [...] (411 aa)
PRELPproline/arginine-rich end leucine-rich repeat protein; May anchor basement membranes to the underlying connective tissue (By similarity) (382 aa)
ST3GAL2ST3 beta-galactoside alpha-2,3-sialyltransferase 2; It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values (350 aa)
FMODfibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity) (376 aa)
HSPG2heparan sulfate proteoglycan 2; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development (4391 aa)
OMDosteomodulin; May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)- integrin (By similarity) (421 aa)
ST3GAL6ST3 beta-galactoside alpha-2,3-sialyltransferase 6; Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3- sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1 (331 aa)
FBLN2fibulin 2; Its binding to fibronectin and some other ligands is calcium dependent (1231 aa)
ACANaggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region (2530 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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