Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
SNX7 SNX7 WDFY1 WDFY1 SNX10 SNX10 WDFY2 WDFY2 SNX2 SNX2 SNX4 SNX4 PLEKHF2 PLEKHF2 SNX1 SNX1 RTN4 RTN4 SNX30 SNX30 RTN1 RTN1 SNX11 SNX11 SNX8 SNX8 UGCG UGCG FXR2 FXR2 UBC UBC PPP2R3C PPP2R3C RTN3 RTN3 TERF1 TERF1 ZNF391 ZNF391 RAB33A RAB33A FGFR1 FGFR1 CDIPT CDIPT PARP2 PARP2 PTPN9 PTPN9 PRTFDC1 PRTFDC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CDIPTCDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns-inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme (213 aa)
SNX8sorting nexin 8; May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network (465 aa)
WDFY1WD repeat and FYVE domain containing 1 (410 aa)
ZNF391zinc finger protein 391; May be involved in transcriptional regulation (By similarity) (358 aa)
FXR2fragile X mental retardation, autosomal homolog 2; RNA-binding protein (673 aa)
PARP2poly (ADP-ribose) polymerase 2; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (583 aa)
SNX4sorting nexin 4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (450 aa)
RAB33ARAB33A, member RAS oncogene family (237 aa)
PPP2R3Cprotein phosphatase 2, regulatory subunit B’’, gamma (453 aa)
RTN1reticulon 1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells (776 aa)
TERF1telomeric repeat binding factor (NIMA-interacting) 1; Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double- stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair [...] (439 aa)
WDFY2WD repeat and FYVE domain containing 2 (400 aa)
PTPN9protein tyrosine phosphatase, non-receptor type 9; Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus (593 aa)
SNX7sorting nexin 7 (451 aa)
PRTFDC1phosphoribosyl transferase domain containing 1; Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage (225 aa)
PLEKHF2pleckstrin homology domain containing, family F (with FYVE domain) member 2 (249 aa)
RTN4reticulon 4 (1192 aa)
SNX10sorting nexin 10; May be involved in several stages of intracellular trafficking (By similarity). May play a role in endosome homeostasis. Overexpression causes formation of huge vacuoles (201 aa)
RTN3reticulon 3 (1013 aa)
UBCubiquitin C (685 aa)
SNX11sorting nexin 11; May be involved in several stages of intracellular trafficking (By similarity) (270 aa)
SNX30sorting nexin family member 30; May be involved in several stages of intracellular trafficking (By similarity) (437 aa)
UGCGUDP-glucose ceramide glucosyltransferase; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase" (394 aa)
SNX2sorting nexin 2; May be involved in several stages of intracellular trafficking. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (519 aa)
FGFR1fibroblast growth factor receptor 1 (853 aa)
SNX1sorting nexin 1; May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (522 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (20%)