Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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 | CFTR | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (1480 aa) | ||
 | ATP1B4 | ATPase, Na+/K+ transporting, beta 4 polypeptide; May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit (357 aa) | ||
 | ABCF2 | ATP-binding cassette, sub-family F (GCN20), member 2 (634 aa) | ||
 | ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 (655 aa) | ||
 | ATP1B2 | ATPase, Na+/K+ transporting, beta 2 polypeptide; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known (290 aa) | ||
 | ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9; Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (1549 aa) | ||
 | ABCA7 | ATP-binding cassette, sub-family A (ABC1), member 7; Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation (2146 aa) | ||
 | ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6; Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis (842 aa) | ||
 | ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 (1527 aa) | ||
 | ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known (279 aa) | ||
 | FXYD2 | FXYD domain containing ion transport regulator 2; May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase (66 aa) | ||
 | ATP4B | ATPase, H+/K+ exchanging, beta polypeptide; Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity (291 aa) | ||
 | CDK5RAP2 | CDK5 regulatory subunit associated protein 2 (1893 aa) | ||
 | ABCA2 | ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development (2436 aa) | ||
 | UBC | ubiquitin C (685 aa) | ||
 | ABCD4 | ATP-binding cassette, sub-family D (ALD), member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm (606 aa) | ||
 | PLN | phospholamban; Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum (52 aa) | ||
 | ABCB8 | ATP-binding cassette, sub-family B (MDR/TAP), member 8 (718 aa) | ||
 | ABCB10 | ATP-binding cassette, sub-family B (MDR/TAP), member 10; May mediate critical mitochondrial transport functions related to heme biosynthesis (By similarity) (738 aa) | ||
 | ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (303 aa) | ||
 | ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter (1545 aa) | ||
 | TAP2 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) (653 aa) | ||
 | ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification (1325 aa) | ||
 | ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (1531 aa) | ||
 | ENSG00000250264 | Uncharacterized protein (843 aa) | ||
 | RPS3 | ribosomal protein S3 (243 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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