node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCA2 | ABCA7 | ENSP00000344155 | ENSP00000263094 | ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development | ATP-binding cassette, sub-family A (ABC1), member 7; Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation | 0.775 |
ABCA2 | ABCB6 | ENSP00000344155 | ENSP00000265316 | ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development | ATP-binding cassette, sub-family B (MDR/TAP), member 6; Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis | 0.917 |
ABCA2 | ABCC1 | ENSP00000344155 | ENSP00000382342 | ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | 0.708 |
ABCA2 | ABCC8 | ENSP00000344155 | ENSP00000374467 | ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development | ATP-binding cassette, sub-family C (CFTR/MRP), member 8; Putative subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release | 0.486 |
ABCA2 | ABCD4 | ENSP00000344155 | ENSP00000349396 | ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development | ATP-binding cassette, sub-family D (ALD), member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm | 0.937 |
ABCA2 | ABCF2 | ENSP00000344155 | ENSP00000222388 | ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development | ATP-binding cassette, sub-family F (GCN20), member 2 | 0.881 |
ABCA2 | ABCG2 | ENSP00000344155 | ENSP00000237612 | ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development | ATP-binding cassette, sub-family G (WHITE), member 2 | 0.655 |
ABCA2 | ATP1B1 | ENSP00000344155 | ENSP00000356789 | ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development | ATPase, Na+/K+ transporting, beta 1 polypeptide; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane | 0.721 |
ABCA2 | ATP1B3 | ENSP00000344155 | ENSP00000286371 | ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development | ATPase, Na+/K+ transporting, beta 3 polypeptide; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known | 0.720 |
ABCA2 | FXYD2 | ENSP00000344155 | ENSP00000292079 | ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development | FXYD domain containing ion transport regulator 2; May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase | 0.720 |
ABCA2 | PLN | ENSP00000344155 | ENSP00000350132 | ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development | phospholamban; Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum | 0.720 |
ABCA2 | UBC | ENSP00000344155 | ENSP00000344818 | ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development | ubiquitin C | 0.515 |
ABCA7 | ABCA2 | ENSP00000263094 | ENSP00000344155 | ATP-binding cassette, sub-family A (ABC1), member 7; Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation | ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development | 0.775 |
ABCA7 | ABCB6 | ENSP00000263094 | ENSP00000265316 | ATP-binding cassette, sub-family A (ABC1), member 7; Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation | ATP-binding cassette, sub-family B (MDR/TAP), member 6; Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis | 0.767 |
ABCA7 | ABCC8 | ENSP00000263094 | ENSP00000374467 | ATP-binding cassette, sub-family A (ABC1), member 7; Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation | ATP-binding cassette, sub-family C (CFTR/MRP), member 8; Putative subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release | 0.442 |
ABCA7 | ABCD4 | ENSP00000263094 | ENSP00000349396 | ATP-binding cassette, sub-family A (ABC1), member 7; Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation | ATP-binding cassette, sub-family D (ALD), member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm | 0.894 |
ABCA7 | ABCF2 | ENSP00000263094 | ENSP00000222388 | ATP-binding cassette, sub-family A (ABC1), member 7; Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation | ATP-binding cassette, sub-family F (GCN20), member 2 | 0.895 |
ABCA7 | ABCG2 | ENSP00000263094 | ENSP00000237612 | ATP-binding cassette, sub-family A (ABC1), member 7; Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation | ATP-binding cassette, sub-family G (WHITE), member 2 | 0.644 |
ABCA7 | ATP1B1 | ENSP00000263094 | ENSP00000356789 | ATP-binding cassette, sub-family A (ABC1), member 7; Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation | ATPase, Na+/K+ transporting, beta 1 polypeptide; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane | 0.720 |
ABCA7 | ATP1B3 | ENSP00000263094 | ENSP00000286371 | ATP-binding cassette, sub-family A (ABC1), member 7; Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation | ATPase, Na+/K+ transporting, beta 3 polypeptide; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known | 0.720 |