node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATOX1 | C21orf2 | ENSP00000316854 | ENSP00000344566 | ATX1 antioxidant protein 1 homolog (yeast); Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | 0.557 |
ATOX1 | UBC | ENSP00000316854 | ENSP00000344818 | ATX1 antioxidant protein 1 homolog (yeast); Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense | ubiquitin C | 0.721 |
C21orf2 | ATOX1 | ENSP00000344566 | ENSP00000316854 | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | ATX1 antioxidant protein 1 homolog (yeast); Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense | 0.557 |
C21orf2 | MAEA | ENSP00000344566 | ENSP00000302830 | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | 0.869 |
C21orf2 | RMND5A | ENSP00000344566 | ENSP00000283632 | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | required for meiotic nuclear division 5 homolog A (S. cerevisiae) | 0.778 |
C21orf2 | RMND5B | ENSP00000344566 | ENSP00000320623 | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | required for meiotic nuclear division 5 homolog B (S. cerevisiae) | 0.778 |
MAEA | C21orf2 | ENSP00000302830 | ENSP00000344566 | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | 0.869 |
MAEA | RMND5A | ENSP00000302830 | ENSP00000283632 | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | required for meiotic nuclear division 5 homolog A (S. cerevisiae) | 0.949 |
MAEA | RMND5B | ENSP00000302830 | ENSP00000320623 | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | required for meiotic nuclear division 5 homolog B (S. cerevisiae) | 0.889 |
MAEA | UBC | ENSP00000302830 | ENSP00000344818 | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | ubiquitin C | 0.943 |
RMND5A | C21orf2 | ENSP00000283632 | ENSP00000344566 | required for meiotic nuclear division 5 homolog A (S. cerevisiae) | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | 0.778 |
RMND5A | MAEA | ENSP00000283632 | ENSP00000302830 | required for meiotic nuclear division 5 homolog A (S. cerevisiae) | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | 0.949 |
RMND5A | UBC | ENSP00000283632 | ENSP00000344818 | required for meiotic nuclear division 5 homolog A (S. cerevisiae) | ubiquitin C | 0.620 |
RMND5B | C21orf2 | ENSP00000320623 | ENSP00000344566 | required for meiotic nuclear division 5 homolog B (S. cerevisiae) | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | 0.778 |
RMND5B | MAEA | ENSP00000320623 | ENSP00000302830 | required for meiotic nuclear division 5 homolog B (S. cerevisiae) | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | 0.889 |
UBC | ATOX1 | ENSP00000344818 | ENSP00000316854 | ubiquitin C | ATX1 antioxidant protein 1 homolog (yeast); Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense | 0.721 |
UBC | MAEA | ENSP00000344818 | ENSP00000302830 | ubiquitin C | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | 0.943 |
UBC | RMND5A | ENSP00000344818 | ENSP00000283632 | ubiquitin C | required for meiotic nuclear division 5 homolog A (S. cerevisiae) | 0.620 |