node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATXN1 | UBC | ENSP00000244769 | ENSP00000344818 | ataxin 1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function | ubiquitin C | 0.596 |
BANP | BTG3 | ENSP00000286122 | ENSP00000344609 | BTG3 associated nuclear protein; Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 ’Ser-15’ phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity) | BTG family, member 3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase | 0.618 |
BTG3 | BANP | ENSP00000344609 | ENSP00000286122 | BTG family, member 3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase | BTG3 associated nuclear protein; Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 ’Ser-15’ phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity) | 0.618 |
BTG3 | CHEK1 | ENSP00000344609 | ENSP00000388648 | BTG family, member 3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase | checkpoint kinase 1; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at ’Ser-178’ and ’Thr-507’ and phosphorylation of C [...] | 0.919 |
BTG3 | CNOT7 | ENSP00000344609 | ENSP00000355279 | BTG family, member 3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase | CCR4-NOT transcription complex, subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translation [...] | 0.664 |
BTG3 | E2F1 | ENSP00000344609 | ENSP00000345571 | BTG family, member 3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase | E2F transcription factor 1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis | 0.576 |
BTG3 | UBC | ENSP00000344609 | ENSP00000344818 | BTG family, member 3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase | ubiquitin C | 0.483 |
CHEK1 | BTG3 | ENSP00000388648 | ENSP00000344609 | checkpoint kinase 1; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at ’Ser-178’ and ’Thr-507’ and phosphorylation of C [...] | BTG family, member 3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase | 0.919 |
CHEK1 | UBC | ENSP00000388648 | ENSP00000344818 | checkpoint kinase 1; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at ’Ser-178’ and ’Thr-507’ and phosphorylation of C [...] | ubiquitin C | 0.998 |
CNOT7 | BTG3 | ENSP00000355279 | ENSP00000344609 | CCR4-NOT transcription complex, subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translation [...] | BTG family, member 3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase | 0.664 |
CNOT7 | UBC | ENSP00000355279 | ENSP00000344818 | CCR4-NOT transcription complex, subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translation [...] | ubiquitin C | 0.734 |
E2F1 | BTG3 | ENSP00000345571 | ENSP00000344609 | E2F transcription factor 1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis | BTG family, member 3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase | 0.576 |
E2F1 | UBC | ENSP00000345571 | ENSP00000344818 | E2F transcription factor 1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis | ubiquitin C | 0.999 |
UBC | ATXN1 | ENSP00000344818 | ENSP00000244769 | ubiquitin C | ataxin 1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function | 0.596 |
UBC | BTG3 | ENSP00000344818 | ENSP00000344609 | ubiquitin C | BTG family, member 3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase | 0.483 |
UBC | CHEK1 | ENSP00000344818 | ENSP00000388648 | ubiquitin C | checkpoint kinase 1; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at ’Ser-178’ and ’Thr-507’ and phosphorylation of C [...] | 0.998 |
UBC | CNOT7 | ENSP00000344818 | ENSP00000355279 | ubiquitin C | CCR4-NOT transcription complex, subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translation [...] | 0.734 |
UBC | E2F1 | ENSP00000344818 | ENSP00000345571 | ubiquitin C | E2F transcription factor 1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis | 0.999 |