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GSTT1 GSTT1 ZC3H6 ZC3H6 GSTT2B GSTT2B SLC31A1 SLC31A1 MKRN2 MKRN2 TM9SF2 TM9SF2 GSTZ1 GSTZ1 TM9SF4 TM9SF4 GSTT2 GSTT2 UBC UBC FBXO25 FBXO25 RHBDD1 RHBDD1 CTNS CTNS ENSG00000232856 ENSG00000232856 VARS VARS EEF1G EEF1G SLC31A2 SLC31A2 MARS MARS ZC3H3 ZC3H3 EEF1E1 EEF1E1 ZC3H8 ZC3H8 WASL WASL CPSF4 CPSF4 CPSF4L CPSF4L AIMP3 AIMP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
MKRN2makorin ring finger protein 2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity) (416 aa)
GSTT2glutathione S-transferase theta 2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity (244 aa)
GSTZ1glutathione S-transferase zeta 1 (216 aa)
WASLWiskott-Aldrich syndrome-like; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (505 aa)
GSTT1glutathione S-transferase theta 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide (240 aa)
SLC31A2solute carrier family 31 (copper transporters), member 2; Involved in low-affinity copper uptake (Potential) (143 aa)
MARSmethionyl-tRNA synthetase (900 aa)
ZC3H3zinc finger CCCH-type containing 3 (948 aa)
FBXO25F-box protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity) (367 aa)
GSTT2Bglutathione S-transferase theta 2B (gene/pseudogene); Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity (244 aa)
CPSF4cleavage and polyadenylation specific factor 4, 30kDa; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U) (269 aa)
EEF1Geukaryotic translation elongation factor 1 gamma; Probably plays a role in anchoring the complex to other cellular components (437 aa)
CPSF4Lcleavage and polyadenylation specific factor 4-like (179 aa)
RHBDD1rhomboid domain containing 1; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the trans [...] (315 aa)
UBCubiquitin C (685 aa)
SLC31A1solute carrier family 31 (copper transporters), member 1; High-affinity, saturable copper transporter involved in dietary copper uptake (190 aa)
VARSvalyl-tRNA synthetase (1264 aa)
TM9SF2transmembrane 9 superfamily member 2; In the intracellular compartments, may function as a channel or small molecule transporter (663 aa)
EEF1E1eukaryotic translation elongation factor 1 epsilon 1; Positive modulator of ATM response to DNA damage (174 aa)
CTNScystinosin, lysosomal cystine transporter; Thought to transport cystine out of lysosomes (400 aa)
AIMP3HCG2043275; Uncharacterized protein (151 aa)
TM9SF4transmembrane 9 superfamily protein member 4 (642 aa)
ZC3H8zinc finger CCCH-type containing 8; Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5’-AGGTCTC-3’ sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis (291 aa)
ZC3H6zinc finger CCCH-type containing 6 (1189 aa)
ENSG00000232856hsa-mir-3654 (206 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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