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IL1RAP | interleukin 1 receptor accessory protein; Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular [...] (687 aa) | |||
IL1RAPL2 | interleukin 1 receptor accessory protein-like 2 (686 aa) | |||
PTPRD | protein tyrosine phosphatase, receptor type, D (1912 aa) | |||
PTPRS | protein tyrosine phosphatase, receptor type, S; Interacts with LAR-interacting protein LIP.1 (1948 aa) | |||
PTPRT | protein tyrosine phosphatase, receptor type, T (1441 aa) | |||
SIRT5 | sirtuin 5; NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting- acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Has weak NAD- dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro (310 aa) | |||
PTPRG | protein tyrosine phosphatase, receptor type, G; Possesses tyrosine phosphatase activity (1445 aa) |