node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTN1 | CSRP1 | ENSP00000377941 | ENSP00000345079 | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | cysteine and glycine-rich protein 1; Could play a role in neuronal development | 0.680 |
ACTN1 | GRB2 | ENSP00000377941 | ENSP00000339007 | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.747 |
ACTN1 | UBC | ENSP00000377941 | ENSP00000344818 | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | ubiquitin C | 0.931 |
BAG3 | UBC | ENSP00000358081 | ENSP00000344818 | BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity | ubiquitin C | 0.972 |
BMI1 | EGFR | ENSP00000365851 | ENSP00000275493 | BMI1 polycomb ring finger oncogene; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ’Lys-119’, rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 | epidermal growth factor receptor | 0.418 |
BMI1 | RNF2 | ENSP00000365851 | ENSP00000356480 | BMI1 polycomb ring finger oncogene; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ’Lys-119’, rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 | ring finger protein 2; E3 ubiquitin-protein ligase that mediates monoubiquitination of ’Lys-119’ of histone H2A, thereby playing a central role in histone code and gene regulation. H2A ’Lys-119’ ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, includ [...] | 0.999 |
BMI1 | SUZ12 | ENSP00000365851 | ENSP00000316578 | BMI1 polycomb ring finger oncogene; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ’Lys-119’, rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 | suppressor of zeste 12 homolog (Drosophila); Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates ’Lys-9’ (H3K9me) and ’Lys-27’ (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A | 0.987 |
BMI1 | UBC | ENSP00000365851 | ENSP00000344818 | BMI1 polycomb ring finger oncogene; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ’Lys-119’, rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 | ubiquitin C | 0.979 |
CRP | CSRP1 | ENSP00000255030 | ENSP00000345079 | C-reactive protein, pentraxin-related; Displays several functions associated with host defense- it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells | cysteine and glycine-rich protein 1; Could play a role in neuronal development | 0.576 |
CRP | GRB2 | ENSP00000255030 | ENSP00000339007 | C-reactive protein, pentraxin-related; Displays several functions associated with host defense- it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.517 |
CSDA | CSRP1 | ENSP00000228251 | ENSP00000345079 | cold shock domain protein A; Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full length mRNA and to short RNA sequences containing the consensus site 5’-UCCAUCA-3’. May have a role in translation repression (By similarity) | cysteine and glycine-rich protein 1; Could play a role in neuronal development | 0.494 |
CSDA | EGFR | ENSP00000228251 | ENSP00000275493 | cold shock domain protein A; Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full length mRNA and to short RNA sequences containing the consensus site 5’-UCCAUCA-3’. May have a role in translation repression (By similarity) | epidermal growth factor receptor | 0.487 |
CSDA | MACF1 | ENSP00000228251 | ENSP00000354573 | cold shock domain protein A; Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full length mRNA and to short RNA sequences containing the consensus site 5’-UCCAUCA-3’. May have a role in translation repression (By similarity) | microtubule-actin crosslinking factor 1 | 0.511 |
CSDA | UBC | ENSP00000228251 | ENSP00000344818 | cold shock domain protein A; Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full length mRNA and to short RNA sequences containing the consensus site 5’-UCCAUCA-3’. May have a role in translation repression (By similarity) | ubiquitin C | 0.979 |
CSRP1 | ACTN1 | ENSP00000345079 | ENSP00000377941 | cysteine and glycine-rich protein 1; Could play a role in neuronal development | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | 0.680 |
CSRP1 | CRP | ENSP00000345079 | ENSP00000255030 | cysteine and glycine-rich protein 1; Could play a role in neuronal development | C-reactive protein, pentraxin-related; Displays several functions associated with host defense- it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells | 0.576 |
CSRP1 | CSDA | ENSP00000345079 | ENSP00000228251 | cysteine and glycine-rich protein 1; Could play a role in neuronal development | cold shock domain protein A; Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full length mRNA and to short RNA sequences containing the consensus site 5’-UCCAUCA-3’. May have a role in translation repression (By similarity) | 0.494 |
CSRP1 | GRB2 | ENSP00000345079 | ENSP00000339007 | cysteine and glycine-rich protein 1; Could play a role in neuronal development | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.517 |
CSRP1 | MACF1 | ENSP00000345079 | ENSP00000354573 | cysteine and glycine-rich protein 1; Could play a role in neuronal development | microtubule-actin crosslinking factor 1 | 0.557 |
CSRP1 | UBC | ENSP00000345079 | ENSP00000344818 | cysteine and glycine-rich protein 1; Could play a role in neuronal development | ubiquitin C | 0.630 |