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SMOX SMOX AOC2 AOC2 CNDP1 CNDP1 CNDP2 CNDP2 ADH4 ADH4 AKR1B1 AKR1B1 AOC3 AOC3 UPB1 UPB1 GATM GATM MAOB MAOB AKR1B10 AKR1B10 CARNS1 CARNS1 MAOA MAOA ALDH3A2 ALDH3A2 EHHADH EHHADH ADH5 ADH5 ADH1B ADH1B HADH HADH HIBADH HIBADH ALDH6A1 ALDH6A1 ASMT ASMT ACOT12 ACOT12 ACYP2 ACYP2 GLYCTK GLYCTK BBOX1 BBOX1 ACYP1 ACYP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
EHHADHenoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (723 aa)
ACYP1acylphosphatase 1, erythrocyte (common) type; Its physiological role is not yet clear (99 aa)
AOC2amine oxidase, copper containing 2 (retina-specific); Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina (756 aa)
BBOX1butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine (387 aa)
HIBADH3-hydroxyisobutyrate dehydrogenase (336 aa)
ADH4alcohol dehydrogenase 4 (class II), pi polypeptide (380 aa)
AKR1B1aldo-keto reductase family 1, member B1 (aldose reductase); Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies (316 aa)
ADH5alcohol dehydrogenase 5 (class III), chi polypeptide; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (374 aa)
ACOT12acyl-CoA thioesterase 12; Hydrolyzes acetyl-CoA to acetate and CoA (555 aa)
ADH1Balcohol dehydrogenase 1B (class I), beta polypeptide (375 aa)
SMOXspermine oxidase (555 aa)
AOC3amine oxidase, copper containing 3 (vascular adhesion protein 1); Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin- independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis (763 aa)
UPB1ureidopropionase, beta; Converts N-carbamyl-beta-aminoisobutyric acid and N- carbamyl-beta-alanine to, respectively, beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide (384 aa)
CNDP2CNDP dipeptidase 2 (metallopeptidase M20 family); Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (475 aa)
MAOAmonoamine oxidase A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (527 aa)
ALDH3A2aldehyde dehydrogenase 3 family, member A2; Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (508 aa)
CNDP1carnosine dipeptidase 1 (metallopeptidase M20 family) (507 aa)
AKR1B10aldo-keto reductase family 1, member B10 (aldose reductase); Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs (316 aa)
MAOBmonoamine oxidase B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (520 aa)
ASMTacetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity (373 aa)
ACYP2acylphosphatase 2, muscle type; Its physiological role is not yet clear (99 aa)
GATMglycine amidinotransferase (L-arginine-glycine amidinotransferase); Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis (423 aa)
HADHhydroxyacyl-CoA dehydrogenase; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA (331 aa)
CARNS1carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine (950 aa)
GLYCTKglycerate kinase (523 aa)
ALDH6A1aldehyde dehydrogenase 6 family, member A1; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (535 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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