Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
|
Your Input:
|
||||
 | SLC35C2 | solute carrier family 35, member C2; May play an important role in the cellular response to tissue hypoxia (365 aa) | ||
 | SDHA | succinate dehydrogenase complex, subunit A, flavoprotein (Fp); Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor (664 aa) | ||
 | MCAT | malonyl CoA-ACP acyltransferase (mitochondrial); Catalyzes the transfer of a malonyl moiety from malonyl- CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondrias (390 aa) | ||
 | SFXN1 | sideroflexin 1; Might be involved in the transport of a component required for iron utilization into or out of the mitochondria (322 aa) | ||
 | CYC1 | cytochrome c-1; This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain (325 aa) | ||
 | GADD45GIP1 | growth arrest and DNA-damage-inducible, gamma interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis (222 aa) | ||
 | MRPL40 | mitochondrial ribosomal protein L40 (206 aa) | ||
 | C2orf18 | chromosome 2 open reading frame 18; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter (371 aa) | ||
 | TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) (808 aa) | ||
 | SLC35F1 | solute carrier family 35, member F1; Putative solute transporter (Potential) (408 aa) | ||
 | PSMB5 | proteasome (prosome, macropain) subunit, beta type, 5 (263 aa) | ||
 | SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3; Uridine diphosphate-N-acetylglucosamine transporter in the Golgi apparatus (325 aa) | ||
 | ABCD3 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity (659 aa) | ||
 | SRSF3 | serine/arginine-rich splicing factor 3; May be involved in RNA processing in relation with cellular proliferation and/or maturation (164 aa) | ||
 | PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) (276 aa) | ||
 | TAP2 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) (653 aa) | ||
 | HLA-C | major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity) (366 aa) | ||
 | HLA-E | major histocompatibility complex, class I, E (358 aa) | ||
 | SLC35B3 | solute carrier family 35, member B3; Mediates the transport of adenosine 3’-phospho 5’- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon (401 aa) | ||
 | LTN1 | listerin E3 ubiquitin protein ligase 1 (1812 aa) | ||
 | SLC35B2 | solute carrier family 35, member B2; Mediates the transport of adenosine 3’-phospho 5’- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF- kappa-B and MAPK pathways (432 aa) | ||
 | SLC35F2 | solute carrier family 35, member F2; Putative solute transporter (Potential) (374 aa) | ||
 | HLA-B | major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity) (362 aa) | ||
 | TAPBP | TAP binding protein (tapasin) (504 aa) | ||
 | SLC35A5 | solute carrier family 35, member A5 (424 aa) | ||
 | B2M | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) (119 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
Share
