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KHK KHK GALM GALM LCT LCT SORD SORD PHPT1 PHPT1 GAA GAA GLB1 GLB1 GANC GANC SI SI PMM1 PMM1 PMM2 PMM2 HKDC1 HKDC1 GNPDA1 GNPDA1 PFKFB2 PFKFB2 MPI MPI GFPT2 GFPT2 PFKFB4 PFKFB4 PFKL PFKL GNPNAT1 GNPNAT1 C12orf5 C12orf5 GFPT1 GFPT1 PFKM PFKM FBP2 FBP2 FBP1 FBP1 PFKFB1 PFKFB1 PGM1 PGM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
C12orf5chromosome 12 open reading frame 5; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53 (270 aa)
PMM1phosphomannomutase 1; Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain (262 aa)
GNPNAT1glucosamine-phosphate N-acetyltransferase 1 (184 aa)
PFKFB46-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4; Synthesis and degradation of fructose 2,6-bisphosphate (469 aa)
PHPT1phosphohistidine phosphatase 1; Exhibits phosphohistidine phosphatase activity (125 aa)
GFPT2glutamine-fructose-6-phosphate transaminase 2; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins (682 aa)
KHKketohexokinase (fructokinase) (298 aa)
LCTlactase; LPH splits lactose in the small intestine (1927 aa)
SIsucrase-isomaltase (alpha-glucosidase); Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides (1827 aa)
SORDsorbitol dehydrogenase; Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm (By similarity) (357 aa)
PMM2phosphomannomutase 2; Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions (By similarity) (246 aa)
PFKLphosphofructokinase, liver; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP (780 aa)
GALMgalactose mutarotase (aldose 1-epimerase); Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) (342 aa)
GAAglucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes (952 aa)
GLB1galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans (677 aa)
GNPDA1glucosamine-6-phosphate deaminase 1; Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity) (289 aa)
MPImannose phosphate isomerase; Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions (423 aa)
GANCglucosidase, alpha; neutral C; Has alpha-glucosidase activity (914 aa)
PFKMphosphofructokinase, muscle; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP (851 aa)
HKDC1hexokinase domain containing 1 (917 aa)
GFPT1glutamine--fructose-6-phosphate transaminase 1; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins (681 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2; Synthesis and degradation of fructose 2,6-bisphosphate (505 aa)
PGM1phosphoglucomutase 1 (580 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1; Synthesis and degradation of fructose 2,6-bisphosphate (471 aa)
FBP1fructose-1,6-bisphosphatase 1 (338 aa)
FBP2fructose-1,6-bisphosphatase 2 (339 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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