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GAA GAA GLB1 GLB1 KHK KHK GALM GALM LCT LCT GANC GANC SORD SORD PMM1 PMM1 PMM2 PMM2 HKDC1 HKDC1 GFPT2 GFPT2 MPI MPI ATP6C ATP6C GPI GPI GFPT1 GFPT1 PFKFB3 PFKFB3 PFKFB4 PFKFB4 C12orf5 C12orf5 GNPDA1 GNPDA1 FBP2 FBP2 PGM2 PGM2 PFKFB1 PFKFB1 PFKP PFKP PFKM PFKM FBP1 FBP1 PFKFB2 PFKFB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
C12orf5chromosome 12 open reading frame 5; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53 (270 aa)
PMM1phosphomannomutase 1; Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain (262 aa)
PFKFB46-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4; Synthesis and degradation of fructose 2,6-bisphosphate (469 aa)
GFPT2glutamine-fructose-6-phosphate transaminase 2; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins (682 aa)
KHKketohexokinase (fructokinase) (298 aa)
LCTlactase; LPH splits lactose in the small intestine (1927 aa)
SORDsorbitol dehydrogenase; Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm (By similarity) (357 aa)
PMM2phosphomannomutase 2; Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions (By similarity) (246 aa)
GALMgalactose mutarotase (aldose 1-epimerase); Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) (342 aa)
GAAglucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes (952 aa)
GLB1galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans (677 aa)
GNPDA1glucosamine-6-phosphate deaminase 1; Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity) (289 aa)
MPImannose phosphate isomerase; Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions (423 aa)
GANCglucosidase, alpha; neutral C; Has alpha-glucosidase activity (914 aa)
PFKMphosphofructokinase, muscle; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP (851 aa)
HKDC1hexokinase domain containing 1 (917 aa)
GFPT1glutamine--fructose-6-phosphate transaminase 1; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins (681 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2; Synthesis and degradation of fructose 2,6-bisphosphate (505 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1; Synthesis and degradation of fructose 2,6-bisphosphate (471 aa)
FBP1fructose-1,6-bisphosphatase 1 (338 aa)
FBP2fructose-1,6-bisphosphatase 2 (339 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3; Synthesis and degradation of fructose 2,6-bisphosphate (520 aa)
PFKPphosphofructokinase, platelet; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP (784 aa)
PGM2phosphoglucomutase 2; Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity (612 aa)
GPIglucose-6-phosphate isomerase; Besides it’s role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons (569 aa)
ATP6CUncharacterized protein (152 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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