node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAR2 | ASCC3 | ENSP00000313674 | ENSP00000358159 | AAR2 splicing factor homolog (S. cerevisiae) | activating signal cointegrator 1 complex subunit 3; 3’-5’ DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation | 0.673 |
AAR2 | HELQ | ENSP00000313674 | ENSP00000295488 | AAR2 splicing factor homolog (S. cerevisiae) | helicase, POLQ-like; DNA-dependent ATPase and 5’ to 3’ DNA helicase | 0.464 |
AAR2 | HFM1 | ENSP00000313674 | ENSP00000359454 | AAR2 splicing factor homolog (S. cerevisiae) | HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) | 0.673 |
AAR2 | POLQ | ENSP00000313674 | ENSP00000264233 | AAR2 splicing factor homolog (S. cerevisiae) | polymerase (DNA directed), theta; Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links | 0.443 |
AAR2 | PRPF8 | ENSP00000313674 | ENSP00000304350 | AAR2 splicing factor homolog (S. cerevisiae) | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | 0.998 |
AAR2 | SNRNP200 | ENSP00000313674 | ENSP00000317123 | AAR2 splicing factor homolog (S. cerevisiae) | small nuclear ribonucleoprotein 200kDa (U5); RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome | 0.987 |
AAR2 | UBC | ENSP00000313674 | ENSP00000344818 | AAR2 splicing factor homolog (S. cerevisiae) | ubiquitin C | 0.942 |
ASCC3 | AAR2 | ENSP00000358159 | ENSP00000313674 | activating signal cointegrator 1 complex subunit 3; 3’-5’ DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation | AAR2 splicing factor homolog (S. cerevisiae) | 0.673 |
ASCC3 | PRPF8 | ENSP00000358159 | ENSP00000304350 | activating signal cointegrator 1 complex subunit 3; 3’-5’ DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | 0.917 |
ASCC3 | UBC | ENSP00000358159 | ENSP00000344818 | activating signal cointegrator 1 complex subunit 3; 3’-5’ DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation | ubiquitin C | 0.929 |
HELQ | AAR2 | ENSP00000295488 | ENSP00000313674 | helicase, POLQ-like; DNA-dependent ATPase and 5’ to 3’ DNA helicase | AAR2 splicing factor homolog (S. cerevisiae) | 0.464 |
HELQ | PRPF8 | ENSP00000295488 | ENSP00000304350 | helicase, POLQ-like; DNA-dependent ATPase and 5’ to 3’ DNA helicase | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | 0.659 |
HFM1 | AAR2 | ENSP00000359454 | ENSP00000313674 | HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) | AAR2 splicing factor homolog (S. cerevisiae) | 0.673 |
HFM1 | PRPF8 | ENSP00000359454 | ENSP00000304350 | HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | 0.882 |
POLQ | AAR2 | ENSP00000264233 | ENSP00000313674 | polymerase (DNA directed), theta; Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links | AAR2 splicing factor homolog (S. cerevisiae) | 0.443 |
POLQ | PRPF8 | ENSP00000264233 | ENSP00000304350 | polymerase (DNA directed), theta; Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | 0.599 |
PRPF8 | AAR2 | ENSP00000304350 | ENSP00000313674 | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | AAR2 splicing factor homolog (S. cerevisiae) | 0.998 |
PRPF8 | ASCC3 | ENSP00000304350 | ENSP00000358159 | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | activating signal cointegrator 1 complex subunit 3; 3’-5’ DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation | 0.917 |
PRPF8 | HELQ | ENSP00000304350 | ENSP00000295488 | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | helicase, POLQ-like; DNA-dependent ATPase and 5’ to 3’ DNA helicase | 0.659 |
PRPF8 | HFM1 | ENSP00000304350 | ENSP00000359454 | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) | 0.882 |