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KCTD2 KCTD2 KCTD17 KCTD17 LRIT3 LRIT3 LRIT1 LRIT1 NID1 NID1 GTPBP2 GTPBP2 GTPBP1 GTPBP1 BCAM BCAM DAG1 DAG1 KCTD5 KCTD5 GIF GIF TCN1 TCN1 UBC UBC IGSF9B IGSF9B HECW2 HECW2 EGFLAM EGFLAM CCNE2 CCNE2 LYZL1 LYZL1 CCNE1 CCNE1 TAPBPL TAPBPL EVX1 EVX1 LYZL2 LYZL2 SLAMF7 SLAMF7 IGSF11 IGSF11 IGDCC3 IGDCC3 EVX2 EVX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
GTPBP1GTP binding protein 1; Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity) (669 aa)
GIFgastric intrinsic factor (vitamin B synthesis); Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis (417 aa)
TCN1transcobalamin I (vitamin B12 binding protein, R binder family); Vitamin B12-binding protein. Transports cobalamin into cells (433 aa)
HECW2HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2; E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (1572 aa)
CCNE1cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition (410 aa)
NID1nidogen 1; Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions (1247 aa)
TAPBPLTAP binding protein-like (468 aa)
BCAMbasal cell adhesion molecule (Lutheran blood group); Laminin alpha-5 receptor. May mediate intracellular signaling (628 aa)
KCTD5potassium channel tetramerisation domain containing 5; Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 (234 aa)
GTPBP2GTP binding protein 2 (602 aa)
CCNE2cyclin E2; Essential for the control of the cell cycle at the late G1 and early S phase (404 aa)
EVX2even-skipped homeobox 2 (476 aa)
DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization (895 aa)
KCTD2potassium channel tetramerisation domain containing 2 (263 aa)
IGSF9Bimmunoglobulin superfamily, member 9B (1349 aa)
IGDCC3immunoglobulin superfamily, DCC subclass, member 3 (814 aa)
UBCubiquitin C (685 aa)
EGFLAMEGF-like, fibronectin type III and laminin G domains (1017 aa)
SLAMF7SLAM family member 7; Isoform 1 mediates NK cell activation through a SH2D1A- independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion (335 aa)
LRIT1leucine-rich repeat, immunoglobulin-like and transmembrane domains 1; Possible role in phototransduction (623 aa)
LYZL2lysozyme-like 2 (194 aa)
LYZL1lysozyme-like 1 (194 aa)
LRIT3leucine-rich repeat, immunoglobulin-like and transmembrane domains 3; Might facilitate FGFR1 exit from the endoplasmic reticulum to the Golgi (634 aa)
IGSF11immunoglobulin superfamily, member 11; Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth (431 aa)
KCTD17potassium channel tetramerisation domain containing 17 (297 aa)
EVX1even-skipped homeobox 1; May play a role in the specification of neuronal cell types (407 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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