Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | MYH9 | myosin, heavy chain 9, non-muscle; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping (1960 aa) | ||
 | VIM | vimentin (466 aa) | ||
 | BIRC2 | baculoviral IAP repeat containing 2; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions- acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for it [...] (618 aa) | ||
 | ZNF426 | zinc finger protein 426; May be involved in transcriptional regulation (554 aa) | ||
 | MID2 | midline 2 (735 aa) | ||
 | ZNF544 | zinc finger protein 544; May be involved in transcriptional regulation (715 aa) | ||
 | BCL6B | B-cell CLL/lymphoma 6, member B; Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development (479 aa) | ||
 | SPERT | spermatid associated (448 aa) | ||
 | ZNF490 | zinc finger protein 490; May be involved in transcriptional regulation (529 aa) | ||
 | ACTG1 | actin, gamma 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (375 aa) | ||
 | ZNF599 | zinc finger protein 599; May be involved in transcriptional regulation (588 aa) | ||
 | HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to [...] (826 aa) | ||
 | TRIM29 | tripartite motif containing 29; It is able to complement the radiosensitivity defect of an ataxia telangiectasia (AT) fibroblast cell line (588 aa) | ||
 | ZNF2 | zinc finger protein 2; May be involved in transcriptional regulation (426 aa) | ||
 | TSGA10 | testis specific, 10; May play a role in the sperm tail fibrous sheath, a major sperm tail structure (By similarity) (698 aa) | ||
 | ZNF670 | zinc finger protein 670; May be involved in transcriptional regulation (389 aa) | ||
 | CDC73 | cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae); Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and [...] (531 aa) | ||
 | SYT6 | synaptotagmin VI; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)- regulation of exocytosis in acrosomal reaction in sperm (By similarity) (425 aa) | ||
 | PPHLN1 | periphilin 1; Involved in epithelial differentiation and contributes to epidermal integrity and barrier formation (458 aa) | ||
 | TUBA3C | tubulin, alpha 3c; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) (450 aa) | ||
 | OBSL1 | obscurin-like 1; Regulates CUL7-FBXW8-containing ubiquitin ligase complex, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Localizes CUL7 to the Golgi apparatus in neurons (1896 aa) | ||
 | CEP44 | centrosomal protein 44kDa (399 aa) | ||
 | ZBTB38 | zinc finger and BTB domain containing 38; Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity) (1195 aa) | ||
 | ZNF410 | zinc finger protein 410; Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence (516 aa) | ||
 | CDK18 | cyclin-dependent kinase 18; May play a role in signal transduction cascades in terminally differentiated cells (504 aa) | ||
 | MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle; Regulatory light chain of myosin. Does not bind calcium (151 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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