Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | PIGU | phosphatidylinositol glycan anchor biosynthesis, class U; Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI (435 aa) | ||
 | EIF3E | eukaryotic translation initiation factor 3, subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] (445 aa) | ||
 | RAB22A | RAB22A, member RAS oncogene family; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (194 aa) | ||
 | GRIK5 | glutamate receptor, ionotropic, kainate 5; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L- glutamate >> AMPA >> NMDA = 1S,3R-ACPD (980 aa) | ||
 | RAB17 | RAB17, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly obse [...] (212 aa) | ||
 | RAB20 | RAB20, member RAS oncogene family; Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes (234 aa) | ||
 | RPS27A | ribosomal protein S27a (156 aa) | ||
 | RAB5A | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension (215 aa) | ||
 | PIGT | phosphatidylinositol glycan anchor biosynthesis, class T (578 aa) | ||
 | RAB24 | RAB24, member RAS oncogene family; May be involved in autophagy-related processes (By similarity) (203 aa) | ||
 | RAB31 | RAB31, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membr [...] (195 aa) | ||
 | UBB | ubiquitin B (229 aa) | ||
 | PIGS | phosphatidylinositol glycan anchor biosynthesis, class S; Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates (555 aa) | ||
 | ARV1 | ARV1 homolog (S. cerevisiae) (271 aa) | ||
 | LGMN | legumain; Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (433 aa) | ||
 | UBC | ubiquitin C (685 aa) | ||
 | RAB5C | RAB5C, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) (216 aa) | ||
 | GPAA1 | glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast); Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate (621 aa) | ||
 | PNLIPRP1 | pancreatic lipase-related protein 1; May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity) (467 aa) | ||
 | RAB5B | RAB5B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) (215 aa) | ||
 | PNLIP | pancreatic lipase (465 aa) | ||
 | PIGK | phosphatidylinositol glycan anchor biosynthesis, class K; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein’s C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (395 aa) | ||
 | PRR13 | proline rich 13; Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane- induced apoptosis (148 aa) | ||
 | RAD23A | RAD23 homolog A (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to ’Lys-48’-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to ’Lys-63’-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome (363 aa) | ||
 | ENSG00000267261 | Ras-related protein Rab-5C (282 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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