adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

adenylate cyclase 4; This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity)

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity)

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

adenylate cyclase 8 (brain); This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity)

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

adenylate cyclase 9; May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity)

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

ectonucleoside triphosphate diphosphohydrolase 2; In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

ectonucleoside triphosphate diphosphohydrolase 3; Has a threefold preference for the hydrolysis of ATP over ADP

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

NME/NM23 family member 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity)

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

pyruvate kinase, muscle

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

polymerase (RNA) I polypeptide B, 128kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity)

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the cen [...]

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

polymerase (RNA) II (DNA directed) polypeptide B, 140kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each ot [...]

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

polymerase (RNA) II (DNA directed) polypeptide D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex s [...]

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

polymerase (RNA) II (DNA directed) polypeptide G; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex s [...]

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

polymerase (RNA) II (DNA directed) polypeptide H; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity)

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the [...]

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

polymerase (RNA) III (DNA directed) polypeptide D, 44kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts [...]

adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

polymerase (RNA) III (DNA directed) polypeptide E (80kD); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-s [...]