26 items (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	MRPL32	mitochondrial ribosomal protein L32 (188 aa)
	MRPL51	mitochondrial ribosomal protein L51 (128 aa)
	MRPS25	mitochondrial ribosomal protein S25 (173 aa)
	MRPS27	mitochondrial ribosomal protein S27 (414 aa)
	MRPL3	mitochondrial ribosomal protein L3 (348 aa)
	MRPS5	mitochondrial ribosomal protein S5 (430 aa)
	MRPL49	mitochondrial ribosomal protein L49 (166 aa)
	ICT1	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (206 aa)
	MRPL39	mitochondrial ribosomal protein L39 (353 aa)
	MRPL13	mitochondrial ribosomal protein L13 (178 aa)
	MRPL38	mitochondrial ribosomal protein L38 (380 aa)
	MRPS12	mitochondrial ribosomal protein S12 (138 aa)
	MRPL45	mitochondrial ribosomal protein L45 (306 aa)
	MRPS11	mitochondrial ribosomal protein S11 (194 aa)
	MRPS33	mitochondrial ribosomal protein S33 (106 aa)
	TUFM	Tu translation elongation factor, mitochondrial; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (455 aa)
	MRPL54	mitochondrial ribosomal protein L54 (138 aa)
	MRPL40	mitochondrial ribosomal protein L40 (206 aa)
	DAP3	death associated protein 3; Involved in mediating interferon-gamma-induced cell death (398 aa)
	MRPL52	mitochondrial ribosomal protein L52 (123 aa)
	MRPL9	mitochondrial ribosomal protein L9 (267 aa)
	MRPL41	mitochondrial ribosomal protein L41; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (137 aa)
	MRPS15	mitochondrial ribosomal protein S15 (257 aa)
	MTIF3	mitochondrial translational initiation factor 3; IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins (278 aa)
	MRPL23	mitochondrial ribosomal protein L23 (153 aa)
	MRPS34	mitochondrial ribosomal protein S34 (218 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DAP3	ICT1	ENSP00000341692	ENSP00000301585	death associated protein 3; Involved in mediating interferon-gamma-induced cell death	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	0.693
DAP3	MRPL23	ENSP00000341692	ENSP00000370930	death associated protein 3; Involved in mediating interferon-gamma-induced cell death	mitochondrial ribosomal protein L23	0.426
DAP3	MRPS12	ENSP00000341692	ENSP00000308845	death associated protein 3; Involved in mediating interferon-gamma-induced cell death	mitochondrial ribosomal protein S12	0.441
DAP3	MRPS15	ENSP00000341692	ENSP00000362208	death associated protein 3; Involved in mediating interferon-gamma-induced cell death	mitochondrial ribosomal protein S15	0.909
DAP3	MRPS27	ENSP00000341692	ENSP00000261413	death associated protein 3; Involved in mediating interferon-gamma-induced cell death	mitochondrial ribosomal protein S27	0.900
DAP3	MRPS5	ENSP00000341692	ENSP00000272418	death associated protein 3; Involved in mediating interferon-gamma-induced cell death	mitochondrial ribosomal protein S5	0.964
DAP3	TUFM	ENSP00000341692	ENSP00000322439	death associated protein 3; Involved in mediating interferon-gamma-induced cell death	Tu translation elongation factor, mitochondrial; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	0.582
ICT1	DAP3	ENSP00000301585	ENSP00000341692	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	death associated protein 3; Involved in mediating interferon-gamma-induced cell death	0.693
ICT1	MRPL13	ENSP00000301585	ENSP00000306548	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L13	0.903
ICT1	MRPL23	ENSP00000301585	ENSP00000370930	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L23	0.951
ICT1	MRPL3	ENSP00000301585	ENSP00000264995	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L3	0.986
ICT1	MRPL32	ENSP00000301585	ENSP00000223324	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L32	0.480
ICT1	MRPL38	ENSP00000301585	ENSP00000308275	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L38	0.455
ICT1	MRPL39	ENSP00000301585	ENSP00000305682	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L39	0.799
ICT1	MRPL40	ENSP00000301585	ENSP00000333401	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L40	0.662
ICT1	MRPL51	ENSP00000301585	ENSP00000229238	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L51	0.934
ICT1	MRPL52	ENSP00000301585	ENSP00000347277	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L52	0.910
ICT1	MRPS11	ENSP00000301585	ENSP00000317376	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein S11	0.729
ICT1	MRPS12	ENSP00000301585	ENSP00000308845	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein S12	0.710
ICT1	MRPS15	ENSP00000301585	ENSP00000362208	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein S15	0.692

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