node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APLP2 | APP | ENSP00000263574 | ENSP00000284981 | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | amyloid beta (A4) precursor protein | 0.595 |
APP | APLP2 | ENSP00000284981 | ENSP00000263574 | amyloid beta (A4) precursor protein | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | 0.595 |
APP | EDN1 | ENSP00000284981 | ENSP00000368683 | amyloid beta (A4) precursor protein | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | 0.917 |
APP | EDN2 | ENSP00000284981 | ENSP00000361668 | amyloid beta (A4) precursor protein | endothelin 2; Endothelins are endothelium-derived vasoconstrictor peptides | 0.912 |
APP | EDN3 | ENSP00000284981 | ENSP00000337128 | amyloid beta (A4) precursor protein | endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides | 0.916 |
EDN1 | APP | ENSP00000368683 | ENSP00000284981 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | amyloid beta (A4) precursor protein | 0.917 |
EDN1 | EDN2 | ENSP00000368683 | ENSP00000361668 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | endothelin 2; Endothelins are endothelium-derived vasoconstrictor peptides | 0.916 |
EDN1 | EDN3 | ENSP00000368683 | ENSP00000337128 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides | 0.923 |
EDN1 | KEL | ENSP00000368683 | ENSP00000347409 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3 | 0.690 |
EDN2 | APP | ENSP00000361668 | ENSP00000284981 | endothelin 2; Endothelins are endothelium-derived vasoconstrictor peptides | amyloid beta (A4) precursor protein | 0.912 |
EDN2 | EDN1 | ENSP00000361668 | ENSP00000368683 | endothelin 2; Endothelins are endothelium-derived vasoconstrictor peptides | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | 0.916 |
EDN2 | EDN3 | ENSP00000361668 | ENSP00000337128 | endothelin 2; Endothelins are endothelium-derived vasoconstrictor peptides | endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides | 0.919 |
EDN2 | KEL | ENSP00000361668 | ENSP00000347409 | endothelin 2; Endothelins are endothelium-derived vasoconstrictor peptides | Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3 | 0.713 |
EDN3 | APP | ENSP00000337128 | ENSP00000284981 | endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides | amyloid beta (A4) precursor protein | 0.916 |
EDN3 | EDN1 | ENSP00000337128 | ENSP00000368683 | endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | 0.923 |
EDN3 | EDN2 | ENSP00000337128 | ENSP00000361668 | endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides | endothelin 2; Endothelins are endothelium-derived vasoconstrictor peptides | 0.919 |
EDN3 | KEL | ENSP00000337128 | ENSP00000347409 | endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides | Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3 | 0.826 |
KEL | EDN1 | ENSP00000347409 | ENSP00000368683 | Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | 0.690 |
KEL | EDN2 | ENSP00000347409 | ENSP00000361668 | Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3 | endothelin 2; Endothelins are endothelium-derived vasoconstrictor peptides | 0.713 |
KEL | EDN3 | ENSP00000347409 | ENSP00000337128 | Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3 | endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides | 0.826 |