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MMP1 MMP1 CTSL2 CTSL2 CTSK CTSK MMP7 MMP7 CTSB CTSB LAMC1 LAMC1 MMP9 MMP9 FOXA1 FOXA1 COL18A1 COL18A1 COL16A1 COL16A1 COL1A2 COL1A2 COL13A1 COL13A1 COL4A2 COL4A2 COL2A1 COL2A1 COL7A1 COL7A1 COL4A5 COL4A5 COL4A3 COL4A3 COL4A6 COL4A6 COL27A1 COL27A1 COL4A4 COL4A4 COL8A2 COL8A2 COL6A2 COL6A2 COL6A1 COL6A1 COL5A2 COL5A2 COL6A3 COL6A3 COL11A1 COL11A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
FOXA1forkhead box A1; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ’pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5’-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3’ (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-spe [...] (472 aa)
LAMC1laminin, gamma 1 (formerly LAMB2); Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components (1609 aa)
CTSL2cathepsin L2; Cysteine protease. May have an important role in corneal physiology (334 aa)
MMP7matrix metallopeptidase 7 (matrilysin, uterine); Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase (267 aa)
CTSKcathepsin K; Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (329 aa)
COL6A3collagen, type VI, alpha 3; Collagen VI acts as a cell-binding protein (3177 aa)
COL1A2collagen, type I, alpha 2 (1366 aa)
COL6A2collagen, type VI, alpha 2 (1019 aa)
COL8A2collagen, type VIII, alpha 2; Macromolecular component of the subendothelium. Major component of the Descemet’s membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity) (703 aa)
MMP1matrix metallopeptidase 1 (interstitial collagenase); Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat’s mediated neurotoxicity (469 aa)
COL4A5collagen, type IV, alpha 5; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen (1691 aa)
COL7A1collagen, type VII, alpha 1; Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen (2944 aa)
CTSBcathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis (339 aa)
COL18A1collagen, type XVIII, alpha 1 (1519 aa)
COL27A1collagen, type XXVII, alpha 1; Plays a role during the calcification of cartilage and the transition of cartilage to bone (1860 aa)
COL4A2collagen, type IV, alpha 2; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen (1712 aa)
COL6A1collagen, type VI, alpha 1; Collagen VI acts as a cell-binding protein (1028 aa)
COL11A1collagen, type XI, alpha 1 (1806 aa)
COL4A6collagen, type IV, alpha 6 (1691 aa)
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide (707 aa)
COL16A1collagen, type XVI, alpha 1; Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology (1604 aa)
COL5A2collagen, type V, alpha 2 (1499 aa)
COL2A1collagen, type II, alpha 1 (1487 aa)
COL4A3collagen, type IV, alpha 3 (Goodpasture antigen) (1670 aa)
COL4A4collagen, type IV, alpha 4; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen (1690 aa)
COL13A1collagen, type XIII, alpha 1 (717 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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