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CFTR | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (1480 aa) | |||
SLC22A4 | solute carrier family 22 (organic cation/ergothioneine transporter), member 4; Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET) (551 aa) | |||
SLC22A5 | solute carrier family 22 (organic cation/carnitine transporter), member 5; Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3 (557 aa) | |||
GUCY2C | guanylate cyclase 2C (heat stable enterotoxin receptor); Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin (1073 aa) | |||
SLC22A3 | solute carrier family 22 (extraneuronal monoamine transporter), member 3; Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain (556 aa) | |||
STAR | steroidogenic acute regulatory protein; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (285 aa) | |||
SLC22A9 | solute carrier family 22 (organic anion transporter), member 9 (553 aa) | |||
PTGIR | prostaglandin I2 (prostacyclin) receptor (IP); Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase (386 aa) | |||
SLCO1A2 | solute carrier organic anion transporter family, member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin (670 aa) | |||
SLCO3A1 | solute carrier organic anion transporter family, member 3A1; Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed-10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3- sulfate, taurocholate, digoxin nor DHEAS (PubMed-16971491) (710 aa) | |||
SLC34A1 | solute carrier family 34 (sodium phosphate), member 1; May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx (639 aa) | |||
SLC41A3 | solute carrier family 41, member 3 (507 aa) | |||
ASAP3 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3; Promotes cell proliferation (903 aa) | |||
PDZD3 | PDZ domain containing 3; Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions (505 aa) | |||
SPRYD7 | SPRY domain containing 7 (196 aa) | |||
CACNA1S | calcium channel, voltage-dependent, L type, alpha 1S subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the ’high-voltage activated’ (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and b [...] (1873 aa) | |||
ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter (1545 aa) | |||
SLC15A1 | solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products (708 aa) | |||
SLCO1C1 | solute carrier organic anion transporter family, member 1C1; Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity) (730 aa) | |||
SLC15A2 | solute carrier family 15 (H+/peptide transporter), member 2; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides (729 aa) |