node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BABAM1 | SFXN4 | ENSP00000352408 | ENSP00000347924 | BRISC and BRCA1 A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes ’Lys-63’-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ’Lys-63’-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprote [...] | sideroflexin 4; Potential iron transporter (By similarity) | 0.740 |
BABAM1 | UBC | ENSP00000352408 | ENSP00000344818 | BRISC and BRCA1 A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes ’Lys-63’-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ’Lys-63’-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprote [...] | ubiquitin C | 0.948 |
CAD | CPS1 | ENSP00000264705 | ENSP00000402608 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell | 0.999 |
CAD | EPRS | ENSP00000264705 | ENSP00000355890 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | glutamyl-prolyl-tRNA synthetase | 0.972 |
CAD | UBC | ENSP00000264705 | ENSP00000344818 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | ubiquitin C | 0.874 |
CLN3 | COX15 | ENSP00000353073 | ENSP00000016171 | ceroid-lipofuscinosis, neuronal 3 | cytochrome c oxidase assembly homolog 15 (yeast); May be involved in the biosynthesis of heme A | 0.640 |
CLN3 | SFXN4 | ENSP00000353073 | ENSP00000347924 | ceroid-lipofuscinosis, neuronal 3 | sideroflexin 4; Potential iron transporter (By similarity) | 0.509 |
CLN3 | UBC | ENSP00000353073 | ENSP00000344818 | ceroid-lipofuscinosis, neuronal 3 | ubiquitin C | 0.924 |
COA3 | UBC | ENSP00000354762 | ENSP00000344818 | cytochrome c oxidase assembly factor 3; Component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex that regulates COX assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly | ubiquitin C | 0.483 |
COX15 | CLN3 | ENSP00000016171 | ENSP00000353073 | cytochrome c oxidase assembly homolog 15 (yeast); May be involved in the biosynthesis of heme A | ceroid-lipofuscinosis, neuronal 3 | 0.640 |
COX15 | UBC | ENSP00000016171 | ENSP00000344818 | cytochrome c oxidase assembly homolog 15 (yeast); May be involved in the biosynthesis of heme A | ubiquitin C | 0.627 |
CPS1 | CAD | ENSP00000402608 | ENSP00000264705 | carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.999 |
CPS1 | EPRS | ENSP00000402608 | ENSP00000355890 | carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell | glutamyl-prolyl-tRNA synthetase | 0.858 |
CPS1 | UBC | ENSP00000402608 | ENSP00000344818 | carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell | ubiquitin C | 0.962 |
EPRS | CAD | ENSP00000355890 | ENSP00000264705 | glutamyl-prolyl-tRNA synthetase | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.972 |
EPRS | CPS1 | ENSP00000355890 | ENSP00000402608 | glutamyl-prolyl-tRNA synthetase | carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell | 0.858 |
EPRS | UBC | ENSP00000355890 | ENSP00000344818 | glutamyl-prolyl-tRNA synthetase | ubiquitin C | 0.997 |
SFXN4 | BABAM1 | ENSP00000347924 | ENSP00000352408 | sideroflexin 4; Potential iron transporter (By similarity) | BRISC and BRCA1 A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes ’Lys-63’-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ’Lys-63’-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprote [...] | 0.740 |
SFXN4 | CLN3 | ENSP00000347924 | ENSP00000353073 | sideroflexin 4; Potential iron transporter (By similarity) | ceroid-lipofuscinosis, neuronal 3 | 0.509 |
SFXN4 | UBC | ENSP00000347924 | ENSP00000344818 | sideroflexin 4; Potential iron transporter (By similarity) | ubiquitin C | 0.633 |