node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADRM1 | PSMD4 | ENSP00000253003 | ENSP00000357879 | adhesion regulating molecule 1; Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion | 0.999 |
ADRM1 | UBQLN3 | ENSP00000253003 | ENSP00000347997 | adhesion regulating molecule 1; Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity | ubiquilin 3 | 0.419 |
NME8 | TXN | ENSP00000199447 | ENSP00000363641 | NME/NM23 family member 8; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds | thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates A [...] | 0.613 |
NME8 | TXNDC2 | ENSP00000199447 | ENSP00000304908 | NME/NM23 family member 8; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds | thioredoxin domain containing 2 (spermatozoa); Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase | 0.885 |
NME8 | TXNDC8 | ENSP00000199447 | ENSP00000363634 | NME/NM23 family member 8; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds | thioredoxin domain containing 8 (spermatozoa); May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm | 0.805 |
PEX10 | PEX12 | ENSP00000288774 | ENSP00000225873 | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | peroxisomal biogenesis factor 12; Required for protein import into peroxisomes | 0.999 |
PEX10 | PEX2 | ENSP00000288774 | ENSP00000349543 | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | peroxisomal biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes | 0.997 |
PEX12 | PEX10 | ENSP00000225873 | ENSP00000288774 | peroxisomal biogenesis factor 12; Required for protein import into peroxisomes | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | 0.999 |
PEX12 | PEX2 | ENSP00000225873 | ENSP00000349543 | peroxisomal biogenesis factor 12; Required for protein import into peroxisomes | peroxisomal biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes | 0.994 |
PEX2 | PEX10 | ENSP00000349543 | ENSP00000288774 | peroxisomal biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | 0.997 |
PEX2 | PEX12 | ENSP00000349543 | ENSP00000225873 | peroxisomal biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes | peroxisomal biogenesis factor 12; Required for protein import into peroxisomes | 0.994 |
PSMD4 | ADRM1 | ENSP00000357879 | ENSP00000253003 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion | adhesion regulating molecule 1; Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity | 0.999 |
PSMD4 | UBQLN3 | ENSP00000357879 | ENSP00000347997 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion | ubiquilin 3 | 0.647 |
TXN | NME8 | ENSP00000363641 | ENSP00000199447 | thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates A [...] | NME/NM23 family member 8; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds | 0.613 |
TXNDC2 | NME8 | ENSP00000304908 | ENSP00000199447 | thioredoxin domain containing 2 (spermatozoa); Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase | NME/NM23 family member 8; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds | 0.885 |
TXNDC8 | NME8 | ENSP00000363634 | ENSP00000199447 | thioredoxin domain containing 8 (spermatozoa); May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm | NME/NM23 family member 8; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds | 0.805 |
UBQLN3 | ADRM1 | ENSP00000347997 | ENSP00000253003 | ubiquilin 3 | adhesion regulating molecule 1; Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity | 0.419 |
UBQLN3 | PSMD4 | ENSP00000347997 | ENSP00000357879 | ubiquilin 3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion | 0.647 |