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CORO1A | coronin, actin binding protein, 1A; May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria- infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes (461 aa) | |||
WASL | Wiskott-Aldrich syndrome-like; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (505 aa) | |||
ACTA2 | actin, alpha 2, smooth muscle, aorta; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (377 aa) | |||
CNN1 | calponin 1, basic, smooth muscle; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity) (297 aa) | |||
HIP1R | huntingtin interacting protein 1 related; Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (1068 aa) | |||
ARPC5L | actin related protein 2/3 complex, subunit 5-like; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity) (153 aa) | |||
CORO1C | coronin, actin binding protein, 1C; May be involved in cytokinesis, motility, and signal transduction (By similarity) (474 aa) | |||
CNN2 | calponin 2; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (309 aa) | |||
CAPZB | capping protein (actin filament) muscle Z-line, beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization (277 aa) | |||
TAGLN3 | transgelin 3 (199 aa) | |||
TAGLN | transgelin; Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence (201 aa) | |||
ACTC1 | actin, alpha, cardiac muscle 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (377 aa) | |||
ACTG2 | actin, gamma 2, smooth muscle, enteric; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (376 aa) | |||
UBB | ubiquitin B (229 aa) | |||
ACTG1 | actin, gamma 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (375 aa) | |||
HIP1 | huntingtin interacting protein 1 (1037 aa) | |||
UBC | ubiquitin C (685 aa) | |||
PLS3 | plastin 3; Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia (630 aa) | |||
ACTB | actin, beta (375 aa) | |||
ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (151 aa) | |||
ACTA1 | actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (377 aa) | |||
TAGLN2 | transgelin 2 (199 aa) | |||
CNN3 | calponin 3, acidic; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (329 aa) | |||
ATXN2 | ataxin 2; Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane (1313 aa) | |||
ACTBL2 | actin, beta-like 2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (By similarity) (376 aa) | |||
DBNL | drebrin-like; Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G- actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse [...] (439 aa) |